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JAHA: Spironolactone can reduce aortic stiffness in patients with refractory hypertension, and has nothing to do with blood pressure changes

 Last Update: 2021-09-11
 Source: Internet
 Author: User

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Aortic stiffness is a patient with arterial hypertensionHeart vascular independent predictors of events
.

Refractory hypertension is usually associated with hyperaldosteronism and is associated with adverse outcomes

Heart blood vessels

Recently, a research article published in JAHA, an authoritative journal in the field of cardiovascular diseases, researchers hypothesized that spironolactone can reduce aortic stiffness in patients with refractory hypertension and is not related to changes in blood pressure
.

The study prospectively recruited patients with uncontrolled blood pressure (≥140/90 mmHg) despite the use of more than 3 antihypertensive drugs (including diuretics)
.

Participants started taking 25 mg/d of spironolactone and increased to 50 mg/d at 4 weeks, while stopping other antihypertensive drugs to maintain a constant average blood pressure

Spironolactone can improve the aortic characteristics of patients with refractory hypertension independently of BP, which may support the hypothesis that aldosterone affects the arterial wall

Original source:

Sudeep R.

Aryal.
et al.
Spironolactone Reduces Aortic Stiffness in Patients With Resistant Hypertension Independent of Blood Pressure Change .
JAHA.

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