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Medical hypernomic, gonogen-promoting hormone-releasing hormone astrogens and anti-androgens have been widely used in the treatment of prostate cancer.
steroid sex hormones affect the function of the heart's ion channels.
, however, few studies have assessed the effects of medical de-trending on arrhyth arrhythmics.
recently, a study published in JAHA, an authoritative journal in the field of cardiovascular disease, included 149 prostate cancer patients who treated prostate cancer with progesterone-releasing hormones combined/not combined with anti-androgens.
researchers recorded changes in the electrical map of the center of the subject's treatment process and its relationship to malignant arrhyth arrhythmics.
QT inter-period (394±32 to 406±39 ms (P<0.001)) compared to baseline QT inter-period and corrected QT inter-period (QTc, 416±27 to 439±31 ms (P<0.001) has been extended.
119 patients (79.9%) had longer QTc intervals than the baseline during treatment.
in 2 patients (1.3%) who did not have structural heart disease, the ontology was reversed (TdP) and cerio-fibrillation (VF) for more than 6 months after starting treatment.
QTc intervals in patients with TdP/VF increased by more than 80 ms compared to pre-treatment.
, however, in patients without TdP/VF, the prevalence of QTc intervals increased by more than 50ms compared to pre-treatment by 11%, while in only 4 patients (3%) QTc intervals increased by more than 80ms compared to pre-treatment intervals.
thus, medical de-trending prolongs QT/QTc intervals in most prostate cancer patients, which can lead to TdP/VFs even in patients who do not have an extended risk of QT interstitiosis before treatment.
QTc interval of more than 50 ms than before treatment may be a predictive factor for the occurrence of TdP/VF.
to prevent the occurrence of malignant arrhyth arrhythmic, the monitoring of QTc interval should be paid attention to in the whole process of medical dissocation.