JAHA: The role of the substitin metal protease 9 in circulating ischemic stroke after mezzanine-related vertebral arteries.

Spontaneous vertebral arterial mezzanine (VAD) is an important cause of post-circulatory ischemic stroke (PCS), but its pathogenesis is not yet clear.
metal protease 9 (MMP-9) is a gelatinase that is involved in inflammation and a variety of vascular diseases, such as aortic mezzanine, but its role in VBD is not yet clear.
, a study published in JAHA, an authoritative journal in the field of cardiovascular disease, aims to clarify the association between serum MMP-9 levels and VAD-related PCS.
researchers recruited 149 PCS patients, 30 of whom were VAD patients, 119 were other causes (non VAD) patients, and 219 were non-stroke patients.
MMP-9 levels within 14 days of a stroke.
vaD group was 59.6 to 15.0 years old, similar to among patients in the non-stroke group (P-0.510), but much younger than non-VAD patients (69.9 to 14.0 years, P-lt;0.001).
the proportion of men and the risk factors of blood vessels in both the VAD and non-VAD groups were significantly higher than in the non-stroke group (P.lt;0.001).
analysis of multiple logistic regressions adjusted for potential conflucting factors and found that for every 100 ng/mL increase in serum MMP-9 levels, VAD (as opposed to non-stroke groups: ratio ratio (OR) was 4.572;95%CI is 2.240-9.333, P.lt;0.001; non-VAD group: OR is 1.819; 95% CI is 1.034-3.200, P=0.038).
This shows that patients with VAD-related PCS have higher levels of serum MMP-9 during the acute stroke than PCS patients with non-stroke patients and other causes, which supports the possibility that extracellular substring degradation proteases may be involved in VAD mechanisms, leading to ischemic events.
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