JAM: The effect of low-fat vegetarian diet on adult overweight body weight, insulin sensitivity, postprandial metabolism and lipid levels of cardiomyocytes and hepatocytes

Being overweight and insulin resistance can lead to type 2 diabetes and other health problems
.

Dietary interventions are urgently needed to address these situations

Being overweight and insulin resistance can lead to type 2 diabetes and other health problems

Design, setup, and participants: This 16-week randomized clinical trial was conducted in Washington, DC from January 2017 to February 2019
.

Of the 3115 people who responded to the flyers in the clinic, newspapers and radio advertisements, 244 met the enrollment criteria after being screened by phone (aged between 25 and 75; body mass index between 28 and 40) )

Intervention measures: The subjects were randomly divided into groups at a ratio of 1:1
.

The intervention group (n=122) followed a low-fat vegetarian diet, and the control group (n=122) did not change their diet for 16 weeks

Main results and measures: In Week 0 and Week 16, use a calibrated scale to assess body weight
.

Double X-ray absorbance is used to measure body composition and visceral fat

Results: Of the 244 subjects, 211 (87%) were women, 117 (48%) were white, and the average age was 54.
4 years (11.
6 years)
.

During these 16 weeks, the intervention group lost 5.

Table 1 OPLS model evaluates the relationship between changes in food thermal effects and the first predicted component

Table 1 OPLS model evaluates the relationship between changes in food thermal effects and the first predicted component

Figure Changes in the thermal effect of lipid levels in food, liver cells and cardiomyocytes in the intervention group and the control group

Figure Changes in the thermal effect of lipid levels in food, liver cells and cardiomyocytes in the intervention group and the control group

Table 2 Using OPLS model to evaluate the relationship between liver fat changes and the first predictive component

Table 2 Using OPLS model to evaluate the relationship between liver fat changes and the first predictive component

Conclusion and relevance: Low-fat vegetarian diet intervention reduces weight by reducing energy intake and increasing postprandial metabolism
.

These changes are related to the decrease of fat in hepatocytes and cardiomyocytes and the increase of insulin sensitivity

Low-fat vegetarian diet intervention reduces weight by reducing energy intake and increasing postprandial metabolism

Kahleova H, Petersen KF, Shulman GI,et al ,Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults: A Randomized Clinical Trial .

, Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults: A Randomized Clinical Trial in this message