JAMA: Effects of vitamin C, corticosteroids and vitamin B1 therapy on organ failure in patients with septic shock.

Recently, researchers examined the effects of vitamin C-corticosteroids combined with vitamin B1 therapy on improving organ damage in patients with infectious shock.
study was conducted at 14 centers in the United States, involving 205 adult sepsis shock patients, who were randomly treated with extraintestinal vitamin C (1500 mg), hydrocodiosin (50 mg) and vitamin B1 (100 mg) for 4 consecutive days (n-103) or placebo (n-102) every 6 hours.
result of the study was a change in the Sequente Organ Failure Assessment (SOFA) score (range 0-24; 0-best) between the group and 72 hours.
secondary results included kidney failure and a 30-day mortality rate.
68 years of age, 90 women, and 200 patients (98 percent) received at least one dose of the study drug.
Overall, there were no significant statistical differences in SOFA scores improvement between groups within 72 hours of joining the group (the average SOFA scores of the intervention group dropped from 9.1 to 4.4 points vs the placebo group fell from 9.2 to 5.1 points; the adjusted average variance -0.8).
the risk of renal failure (31.7 percent in the intervention group vs. 27.3 percent in the placebo group; 0.03 percent after correction) or 30-day mortality (34.7 percent vs. 29.3 percent, respectively; and a 1.3 percent risk ratio) was not significant.
The most common serious adverse events were hyperglycemia (12 in the intervention group, 7 in the placebo group), hypernatemia (11 and 7 cases, respectively) and new hospital-approved infections (13 and 12 cases, respectively).
in patients with sepsis shock, the combined use of vitamin C, corticosteroids, and vitamin B1 had no significant effect on improving the assessment score of sequentia organ failure in patients.
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