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JAMA Intern Med: Association of Immune Dysfunction After SARS-CoV-2 Vaccination with COVID-19 Breakthrough Infection

 Last Update: 2022-01-21
 Source: Internet
 Author: User

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Background: Immunocompromised patients are at higher risk for severe COVID-19 outcomes

Immunocompromised patients are at higher risk for severe COVID-19 outcomes

Design, setting, and participants: This retrospective cohort study analyzed data from the National COVID-19 Cohort Collaboration (N3C), a partner that developed a secure, central electronic medical record-based Repository that stores COVID-19 clinical data from academic medical centers across the United States

Key outcomes and measures: Vaccination, diagnosis of COVID-19, diagnosis of immune dysfunction (ie, HIV infection, multiple sclerosis, rheumatoid arthritis, solid organ transplantation and bone marrow transplantation), other complications and demographic data passed N3C data enclave access

RESULTS: A total of 664 722 patients were included in the N3C sample

Conclusions and significance: This cohort study found that adequate vaccination was associated with a reduced risk of COVID-19 breakthrough infection, regardless of the patient's immune status

This cohort study found that adequate vaccination was associated with a reduced risk of COVID-19 breakthrough infection, regardless of the patient's immune status

Association Between Immune Dysfunction and COVID-19 Breakthrough Infection After SARS-CoV-2 Vaccination in the US.
JAMA

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