JAMA Intern Med: Study of specific neutrality and antibody titration in patients recovering from neo-coronary pneumonia.

Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronary Virus 2 (SARS-Cov-2), is threatening the global public health system, but the relationship between the clinical characteristics of the virus and viral and antibody (Nabs) has not been fully studied.
recently examined the relationship between Nabs levels and clinical characteristics in patients recovering from neo-coronary pneumonia.
175 patients with mild neo-coronary pneumonia were involved in the study, and the SARS-cov-2 infection was diagnosed and confirmed by retrovirus-polymerase chain reaction testing in nasopharyngeal samples.
end of the study was patient SARS-CoV-2 specific Nab titration, and the secondary endpoint was Nab dynamics and clinical information.
175 patients, 93 were women, with an average age of 50 years, an average length of hospital stay of 16 days and an average course of 22 days.
patients were discharged from the hospital with varying degrees of SARS-CoV-2-specific Nabs (half of the inhibited doses (ID50, 1076), of which 10 patients had antibody titration below the detection limit (-lt;40) and 2 patients had higher titrations of 15989 and 21567, respectively.
can detect antibodies 4-6 days after onset, peaking at 10-15 days.
Nabs and SARS-related CoV are not cross-reactive.
82 male patients were discharged with antibody titrations higher than 93 female patients (1417 vs 905) and remained follow-up after discharge (1049 vs 751).
56 elderly patients (1537) and 63 middle-aged patients (1291) had antibody titrations higher than 56 young patients (459).
antibody titration was associated with the concentration of C-reactive protein at the time of diagnosis, but not with lymphocyte counts.
specific neutrality and antibody titration in patients recovering from mild and moderate neo-coronary pneumonia were significant.
.