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The number of people with diabetes worldwide has been rising in recent years, with figures showing an expected 50 per cent increase to 439 million by 2030.
neuropathy (DPN) is one of the most common vascular complications in diabetics and the leading cause of disability and death in diabetics, with more than 50 percent of DPN patients affected by pain leading to disability and disability.
guidelines recommend the use of anticonvulsants, antidepressants or local analgesics to treat DPN pain.
to better understand pain management in DPN patients, a recent study published in JAMA Netw Open explored the use of pain medications in newly diagnosed DPN patients.
In this retrospective cohort study, researchers used electronic health records from the Mayo Clinic to analyze the use of first-line painkillers in 3,495 newly diagnosed adults with DPN between January 1, 2014 and December 31, 2018.
all patients were prescribed within the first year of diagnosis and were not prescribed for the previous 12 or 3 months.
The drug use is divided into drugs recommended by the guidelines (pre-Gabalin, gabatin and oxycodone-denephrine reuptake inhibitors); non-recommended opioids; and acceptable drugs (local analgesics, tricyclosan antidepressants, and other anticonvulsants).
3,495 newly diagnosed DPN adults, 1,406 started using new painkillers after diagnosis, according to the study.
between 2014 and 2018, the proportion of patients newly diagnosed with DPN using painkillers fell from 45.6 percent in 2014 to 35.2 percent in 2018.
DPN patients with depression, arthritis and back pain were most likely to start treatment.
of the 1,406 patients treated, 43.8 percent used opioids, 42.9 percent used recommended drugs, and 20.6 percent used acceptable drugs.
men were more likely to use opioids than those who used other drugs, while patients with combined fibromyalgia were less likely to use opioids.
patients with combined arthritis are less likely to use the recommended medications in the guidelines.
over time, opioid use declined, while the rate of use of recommended drugs in the guidelines increased.
overall, opioid use is higher than previously reported, with patients with lifelong pain syndrome using such a high percentage of opioids.