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JAMA Netw Open: Back pot for years? Obesity may not be a risk factor for noncommunicable diseases!

 Last Update: 2021-03-17
 Source: Internet
 Author: User

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Diabetes Bradford Hill has evidence that in older people with acute or chronic diseases, obese patients live longer than thin people.

The link between obesity and the adverse consequences of these chronic diseases is usually attributed to two potential mediators: chronic inflammation and hyperinsulinemia.

For this reason, some researchers have summarized the evidence of the time correlation between high body mass index (BMI) and chronic inflammation and hyperinsulinemia.

The researchers searched the MEDLINE (1946 to August 20, 2019) and Embase (1974 to August 19, 2019) databases, but due to the large amount of results, only studies published in 2018 were included.

In 1865 records, 60 eligible studies were identified, involving 5603 participants in 112 cohorts.

Bubble chart of the time correlation between changes in period 1 and period 2

Bubble chart with time correlation between changes in period 1 and cycle 2 Bubble chart with time correlation between changes in period 1 and period 2 Bubble chart with time correlation between changes in period 1 and period 2

This systematic review and meta-analysis showed that it is more likely that fasting insulin levels fall before weight loss than fasting insulin levels fall after weight loss.

Together with the obesity paradox, this finding suggests that some of the adverse consequences currently attributed to obesity may be caused by hyperinsulinemia or other direct factors.

References: Wiebe N, Ye F, Crumley ET, Bello A, Stenvinkel P, Tonelli M.
Temporal Associations Among Body Mass Index, Fasting Insulin, and Systemic Inflammation :A Systematic Review and Meta-analysis .
JAMA Netw Open.
2021;4 (3):e211263.
com/journals/jamanetworkopen/fullarticle/2777423" target="_blank" rel="noopener">doi:10.
1001/jamanetworkopen.
2021.
1263 References: Wiebe N, Ye F, Crumley ET, Bello A, Stenvinkel P, Tonelli M.
Temporal Associations Among Body Mass Index, Fasting Insulin, and Systemic Inflammation : A Systematic Review and Meta-analysis .
JAMA Netw Open.
2021;4(3):e211263.
com/journals/jamanetworkopen/fullarticle/2777423" target="_blank" rel="noopener">doi:10.
1001/jamanetworkopen.
2021.
1263 References:Wiebe N, Ye F, Crumley ET, Bello A, Stenvinkel P, Tonelli M.
Temporal Associations Among Body Mass Index, Fasting Insulin, and Systemic Inflammation : A Systematic Review and Meta-analysis .
JAMA Netw Open.
2021;4(3) :e211263.
com/journals/jamanetworkopen/fullarticle/2777423" target="_blank" rel="noopener">doi:10.
1001/jamanetworkopen.
2021.
1263 Wiebe N, Ye F, Crumley ET, Bello A, Stenvinkel P, Tonelli M.
Temporal Associations Among Body Mass Index, Fasting Insulin, and Systemic Inflammation : A Systematic Review and Meta-analysis : .
JAMA Netw Open.
2021;4(3):e211263.
com/journals/jamanetworkopen/fullarticle/2777423" target="_blank" rel="noopener">doi:10.
1001/jamanetworkopen.
2021.
1263com/journals/jamanetworkopen/fullarticle/2777423" target="_blank" rel="noopener"> doi:10.
1001/jamanetworkopen.
2021.
1263 leave a message here

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