JAMA Netw Open: Is family history of breast cancer associated with breast density in premenopausal women?

Women with a positive family history of breast cancer (FHBC) in first- degree relatives (mother, sister) have a 2- to 4-fold increased risk of breast cancer

Women with a positive family history of breast cancer (FHBC) in first- degree relatives (mother, sister) have a 2- to 4-fold increased risk of breast cancer

Briefly, family history of breast cancer (FHBC) and breast density on mammography are independent risk factors for breast cancer, but the relationship between FHBC and breast density in premenopausal women is unclear

This single-center cohort study investigated two retrospective cohorts: a discovery cohort of 375 premenopausal women and a validation cohort of 14,040 premenopausal women

This single-center cohort study investigated two retrospective cohorts: a discovery cohort of 375 premenopausal women and a validation cohort of 14,040 premenopausal women

The primary outcome was a quantitative measure of breast density expressed as volume percent density using Volpara (discovery set) and BI-RADS (Breast Imaging Reporting and Data System) breast density (validation set)

Findings showed that the discovery and validation sets had similar characteristics among the 14,415 premenopausal women included in the study

Association of Breast Cancer Family History, Density Volume Percentage, and BI-RADS Breast Density Category

Association of Breast Cancer Family History, Density Volume Percentage, and BI-RADS Breast Density Category Relationship of Breast Cancer Family History, Density Volume Percentage, and BI-RADS Breast Density Category

In the validation dataset, FHBC-positive women were more likely to have dense breasts than women without FHBC (BI-RADS 3-4)

In the validation dataset, FHBC-positive women were more likely to have dense breasts than women without FHBC (BI-RADS 3-4)

In conclusion, in this cohort study, FHBC was positively associated with mammography in premenopausal women

References: Han Y, Moore JX, Colditz GA, Toriola AT.
Family History of Breast Cancer and Mammographic Breast Density in Premenopausal Women.
JAMA Netw Open.
2022;5(2):e2148983.
doi:10.
1001/jamanetworkopen.
2021.
48983 References In: Han Y, Moore JX, Colditz GA, Toriola AT.
Family History of Breast Cancer and Mammographic Breast Density in Premenopausal Women.
  JAMA Netw Open.
 2022;5(2):e2148983.
doi:10.
1001/jamanetworkopen.
2021.
48983 JAMA Netw Open.
JAMA doi: 10.
1001/jamanetworkopen.
2021.
48983

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