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In the United States, lung neuroendocrine tumors or bronchopulmonary carcinoids account for 1-2% of lung cancers
.
About 90% are typical carcinoid (TC) and 10% are atypical carcinoid (AC)
Ectopic ACTH secretion in lung tumors that cause Cushing’s syndrome is associated with a high incidence
.
Because the knowledge is based on rare reports of very few patients, the best management remains unclear
manage
Surgical resection is the standard treatment and can be cured in selected patients with CS with EAS bronchial carcinoid
.
However, there is currently no uniform surgical guideline, from wedge resection to pneumonectomy to bronchial sleeve resection for central tumors
The purpose of this study is to describe the outcome of pulmonary neuroendocrine tumors associated with Cushing syndrome
.
Design, environment, and participants : A series of observational cases from 1982 to 2020 were reviewed in a single institution referral center
.
Kaplan-Meier analysis estimates disease-free survival (DFS)
Design, environment and participants Design, environment and participants
Exposure : lobectomy or pneumonectomy and sublobectomy
.
Main outcomes and indicators : disease-free survival, disease persistence/recurrence
.
result
Result resultAmong 68 patients, the median age was 41 years (17-80 years), males accounted for 42.
6% (29/68), whites accounted for 81.
8% (54/66), and the average follow-up was 16 months (0.
1-341 months).
)
.
Lobectomy is the most common operation (48/68[70.
The surgical morbidity rate was 19.
The 5-year DFS of patients who received radical surgical intervention was 73.
in conclusion
Conclusion conclusionIn this case series, compared with quiescent bronchial carcinoids, EAS carcinoids with CS appear to be associated with increased lymph node metastasis, higher recurrence (mainly local) at 5 and 10 years, and lower overall DFS , Has nothing to do with histological subtype
.
However, we believe that these tumors are not biologically aggressive because these patients have unique, prolonged survival and delayed recurrence
Compared with quiescent bronchial carcinoids, EAS carcinoids with CS appear to be associated with increased lymph node metastasis, higher recurrence (mainly local) at 5 and 10 years, and lower overall DFS, and is associated with histological subtypes nothing to do we believe that these tumors are not aggressive in biology, because these patients have a unique, extended time to recurrence-free survival and delay potential carcinoid tumor biology may not be as severe symptoms of hormone physiology future studies may test when When the endocrine function returns to normal and the sequelae of CS subsides, is the lung-sparing surgical method combined with conventional lymphadenectomy the best intervention in this situation
Original link: https://pubmed.
Outcomes of Surgical Management by Characterization of Lung Neuroendocrine Tumors Associated With Cushing Syndrome Characterization of Outcomes by Surgical Management of Lung Neuroendocrine Tumors Associated With Cushing Syndrome in this message
