JAMA Netw Open: Supplementing high doses of vitamin D during pregnancy does not improve neurodevelopment in future generations

Vitamin D deficiency is a series of conditions manifested by vitamin D deficiency, which may be caused by insufficient vitamin D intake and insufficient exposure to sunlight, or it may be a disorder in the body that restricts the absorption of vitamin D.
vitamin D deficiency is a major global health problem affecting people of all ages and ethnicities.
studies have shown that vitamin D deficiency during pregnancy is associated with a range of neurodevelopmental and mental illnesses, such as attention deficit/ADHD, autism and schizophrenia.
, the results of the study on the relationship between vitamin D intake during pregnancy and neurodevelopment in newborns are not consistent.
, a recent study published in JAMA Netw Open showed that high doses of vitamin D (2800 IU / d) during pregnancy do not improve neurodevelopmental outcomes in offspring compared to the standard recommended dose (400 IU / d).
the study, researchers conducted a two-dose study of 623 pregnant women in Denmark who participated in the COPSAC-2010 queue from 4 March 2009 to 17 November 2010: high-dose vitamin D group (n-315) and standard dose group (n-308).
At the same time, the children of these pregnant women were followed up, and the researchers conducted 12 follow-ups of 551 children from birth to 6 years of age, including high-dose vitamin D groups (n=277) and standard dose groups (n=274) to conduct in-depth assessments of neurodevelopment.
study showed that high doses of vitamin D during pregnancy were supplemented during language testing, vocabulary did not change at age 1, and word volume decreased at age 2, showing similar results in girls and boys.
of vitamin D supplementation was not different from that of the standard dose group.
, when neurodevelopmental assessments were conducted, the addition of high doses of vitamin D had no effect on the overall cognitive score of 3-year-olds compared to the standard dose.
, however, girls' overall motor skills declined, while boys did not differ.
, they were not affected by vitamin D levels in the mood and behavior questionnaire scores.
, compared to the standard recommended dose of vitamin D, high doses of vitamin D in pregnant women later in pregnancy do not improve the neurodevelopment of their offspring.