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    Home > Active Ingredient News > Antitumor Therapy > JAMA Netw Open: The incidence of colorectal cancer has risen sharply. Prevention will begin at the age of 35?!

    JAMA Netw Open: The incidence of colorectal cancer has risen sharply. Prevention will begin at the age of 35?!

    • Last Update: 2021-06-28
    • Source: Internet
    • Author: User
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    Worldwide, colorectal cancer ( CRC ) is the third most common cancer
    .


    According to the latest global cancer statistics analysis, in 2020 , there will be 148,000 newly diagnosed colorectal cancer patients in the United States and 53,000 deaths


    Worldwide, in colorectal cancer ( CRC worldwide, with colorectal cancer ( colorectal colorectal cancer CRC ) is the third most common cancer


    Although there is no clear definition of early-onset CRC , in the published literature, before the age of 50 is the most common screening standard
    .


    The 2020 epidemiological surveillance report from the United States stated that the incidence of CRC from 49 to 50 years old has risen sharply, and there is a higher rate of early CRC diagnoses at the age of 50 .
    Recently, a study published in JAMA Netw Open analyzed the overall survival of individuals with early-onset CRC .

    Although there is no clear definition of early-onset CRC , in the published literature, before the age of 50 is the most common screening standard


    The cohort study used data from the National Cancer Database, included 2004 Nian 1 Yue 1 to 2015 Nian 12 Yue 31 Ri was diagnosed with CRC at age 0 to 90 years of age 769 871 patients
    .


    Among them, patients between 51 and 55 years old served as the control group and defined it as late onset CRC


    The cohort study used data from the National Cancer Database, included 2004 Nian 1 Yue 1 to 2015 Nian 12 Yue 31 Ri was diagnosed with CRC at age 0 to 90 years of age 769 871 patients


    The results showed that in the 769 871 Ming CRC patients, of which 49.
    1% were female, 82.


    The age and stage distribution of patients with colorectal cancer in the National Cancer Database

    The age and stage distribution of patients with colorectal cancer in the National Cancer Database

    However, after adjusting for other factors associated with mortality, with 51 Zhi 55 -year-old diagnosed CRC patients compared with early-onset CRC lower risk of death
    .


    In the stage-adjusted model, the HR of patients with early-onset CRC was 0.
    89 ( 95% CI , 0.


    However, after adjusting for other factors associated with mortality, and with 51 Zhi 55 diagnosed in the age of CRC compared to patients with early-onset CRC lower risk of death


    Mortality estimates for early-onset and late-onset colorectal cancer

    Mortality estimates for early-onset and late-onset colorectal cancer

    In addition, between the ages of 35 to 39 (adjusted HR , 0.


    88 [95% CI , 0.
    84-0.


    In addition, between the ages of 35 to 39 (adjusted HR , 0.


    In short, in this cohort study using a large US database, it was found that in this cohort study using a large US database, it was found that the proportion of individuals diagnosed with early CRC at the age of 50 has increased, and the mortality rate has temporarily decreased .
    However, individuals with early-onset CRC are more likely to be diagnosed as late and have a lower overall survival rate .
    Compared with individuals diagnosed with CRC between the ages of 51 and 55 , patients with early-onset CRC have a higher survival rate .
    However, this advantage in 35 Zhi 39 people in the age of diagnosis is the biggest, but mainly limited to diagnosis I phase and II of the people .
    At the age of 50 , the proportion of individuals diagnosed with early CRC has increased, and the mortality rate has temporarily decreased


    Original source

    En Cheng, MD, PhD 1 ;Holly N.
    Blackburn, MD 2 ;Kimmie Ng, MD, MPH 3 ;et al.
    Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database .
    JAMA Netw Open.
    2021; 4(6):e2112539.
    doi:10.
    1001/jamanetworkopen.
    2021.
    12539

    En Cheng, MD, PhD 1 1 1 ;Holly N.
    Blackburn, MD 2 ;  Kimmie Ng, MD, MPH 3 ;  Holly N.
    Blackburn, MD 2 2 Kimmie Ng, MD, MPH 3 3 et al.
    Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database .
    Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database JAMA Netw Open.
      2021;4(6):e2112539.
    doi:10.
    1001/jamanetworkopen.
    2021.
    12539 JAMA Netw Open.
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