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JAMA Neurol: Drug-eluting stents can significantly reduce the risk of intrastent stenosis and stroke recurrence in patients with high-grade ICAS!

 Last Update: 2022-01-07
 Source: Internet
 Author: User

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Intrastent restenosis (ISR) is the main cause of recurrence of stroke in patients treated with standard bare metal stents (BMS) after intracranial stent surgery

Stroke JAMA

From April 27, 2015 to November 16, 2018, a prospective, multi-center, open-label randomized clinical trial was conducted in 16 medical centers in China with a large amount of intracranial stent operations, and the results were blinded Assessment

Patients were randomly assigned to receive DES (NOVA intracranial sirolimus eluting stent system) or BMS (Apollo intracranial stent system) treatment with a ratio of 1:1

Results A total of 263 participants (194 males [73.

In general, the 1-year ISR rate of the DES group was lower than that of the BMS group, and the overall risk was reduced by 76% (10 [9.

Difference in risk of stent internal stenosis within 1 year of follow-up between DES group and BMS group

Among them, the recurrence rate of ischemic stroke in the DES group from day 31 to year 1 was also significantly lower, and the risk was reduced by 90% (1 [0.

Compared with BMS, DES can reduce the risk of ISR and recurrence of ischemic stroke in symptomatic high-grade ICAS patients

Jia B, Zhang X, Ma N, et al.

Comparison of Drug-Eluting Stent With Bare-Metal Stent in Patients With Symptomatic High-grade Intracranial Atherosclerotic Stenosis: A Randomized Clinical Trial.

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