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JAMA Neurology: Efficacy and safety of rituximab in the treatment of new-onset myasthenia gravis

 Last Update: 2022-09-30
 Source: Internet
 Author: User

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Empirical evidence suggests that rituximab is a third-line option for refractory systemic muscle weakness (MG), but its effect on emerging disease is unknown
.

The randomized, double-blind, placebo-controlled study was conducted in 7 regional clinics in Sweden for 48 weeks
.

The results showed that of the 87 patients who may have been eligible, 25 were randomly assigned to rituximab (mean [SD] age, 67.

In summary, a single dose of 500 mg of rituximab is associated
with a greater probability of minimal MG performance and reduced need for rescue drugs compared with placebo.

References:

Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis: The RINOMAX Randomized Clinical Trial.

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