JAMA Neurology: How does the length of sleep affect cognitive function?

Aging is related to strong changes in sleep, which are caused by changes in life>
.
These changes are not uniform, but heterogeneous.

In this way, Joseph R.
Winer of Stanford University and others explored the relationship between self-reported sleep time and brain Aβ burden, as well as the demographic, cognitive, and life>
.
This sample size gives us the opportunity to examine the linearity of the results in a large elderly population (i.

They hypothesize that multiple independent variables play a role in sleep time.
For example, greater Aβ burden is related to short sleep time, but worse age-related cognitive and life>
.

This cross-sectional study obtained data from participants in the anti-amyloid treatment (A4) study of asymptomatic Alzheimer's disease, which was conducted in 67 locations in the United States, Canada, Australia, and Japan

The samples for this analysis included people aged 65 to 85 who underwent Aβ positron emission tomography (PET), had complete lipoprotein E (APOE) genotype data, and were determined to be clinically normal (according to the clinical dementia score) It is 0) and cognitive accessibility (according to the mini mental status check score of 25 to 30, and the logical memory delayed recall test score of 6 to 18)
.
The data from April 3, 2020 to June 20, 2021 were analyzed

The main labor ending
.
The result is the self-reported night sleep time (according to short-term sleep time: ≤6 hours, normal sleep time.

The 4,417 participants in the study included 2,618 women (59%), with a mean (SD) age of 71.
3 (4.

There was no difference in Aβ between the long sleep time group and the normal sleep time group (β [SE] = 0.
00 [0.
01]; P = .
99)
.

However, compared with normal sleep time, both short and long sleep time are associated with higher body mass index (short and normal sleep time: β [SE] = 0.
48 [0.
17], P = .
01; long and normal sleep time : Β [SE] = 0.
97 [0.
31], P =
.
002), depressive symptoms (short and normal sleep time: β[SE]=0.

The important significance of this study lies in the findings: Both short and long sleep time are related to worse results in the elderly , such as greater Aβ burden, greater depressive symptoms, higher body mass index, and cognitive decline.
The importance of maintaining adequate sleep
.

Original source:
Winer JR, Deters KD, Kennedy G, et al.
Association of Short and Long Sleep Duration With Amyloid-β Burden and Cognition in Aging.