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Clinical studies have reported that COVID-19 patients have symptoms such as myalgia, elevated creatine kinase levels, and persistent muscle weakness
.
Does SARS-CoV-2 infection have covid -19 related myopathy? Is this disease a post-virus phenomenon? There is no research report at present
COVID-19 infection
Recently, JAMA Neurology published a report on histopathological, virological, immunological and ultrastructural research results of skeletal muscle samples from individuals who died from severe COVID-19 , and compared them with skeletal muscle samples from non-COVID-19 critically ill patients.
Compare
.
This case-control autopsy study included patients with COVID-19 or other major diseases who died between March 2020 and February 2021 and underwent an autopsy
.
Individuals who had informed consent to anatomy were randomly selected and the anatomy interval was no more than 6 days
43 cases of COVID-19 patients (median age [quartile range], 72[16] years; 31 males (72%) and 11 non-COVID-19 patients (median age [quartile range] Range], 71[5] years old; including 7 males (64%)
.
Skeletal muscle samples from patients who died from COVID-19 showed higher overall pathology scores (mean [SD], 3.
4 [1.
8] vs 1.
5 [1.
0]; 95% confidence interval, 0-3; P<0.
001) and higher Inflammation score (mean [SD], 3.
5 [2.
1] vs 1.
0 [0.
6]; 95% confidence interval, 0-4; P <0.
001)
.
Among 42 specimens of COVID-19 patients, 23 cases (55%) were related to the expression of MHC class I antigens on the muscle fiber membranes, and 7 cases (17%) of 42 cases of COVID-19 patients had up-regulated expressions of MHC class II antigens, but in the control group None were found
Skeletal muscle samples from patients who died from COVID-19 showed higher overall pathology scores Skeletal muscle samples from patients who died from COVID-19 showed higher overall pathology scores and higher inflammation scores and higher inflammation scores
Compared with COVID-19 patients, skeletal muscle inflammation changes in non-COVID-19 critically ill patients
Compared with COVID-19 patients, skeletal muscle inflammation changes in non-COVID-19 critically ill patientsImmunohistochemistry showed natural killer cells, no SARS-CoV-2 spike protein was detected
Immunohistochemistry showed natural killer cells, no SARS-CoV-2 spike protein was detectedThe inflammatory characteristics of skeletal muscle are more than that of myocardium, and the inflammation is most obvious in patients with chronic COVID-19
.
In some muscle samples, SARS-CoV-2 RNA was detected by PCR reaction, but immunohistochemistry and electron microscopy did not find evidence of direct viral infection of muscle fibers
Skeletal muscle has more inflammatory features than myocardium, and inflammation is most obvious in patients with chronic COVID-19
Most severely ill patients with COVID-19 show symptoms of myositis ranging from mild to severe
Aschman T, Schneider J, Greuel S, et al.
Aschman T, Schneider J, Greuel S, et al.
Association Between SARS-CoV-2 Infection and Immune-Mediated Myopathy in Patients Who Have Died.
JAMA Neurol.
Published online June 11, 2021.
doi:10.
1001/jamaneurol.
2021.
2004 Aschman T , Schneider J, Greuel S, et al.
Association Between SARS-CoV-2 Infection and Immune-Mediated Myopathy in Patients Who Have Died.
JAMA Neurol.
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