JAMA Oncol: 150,000 people followed for 30 years and found that weight loss in diabetics was associated with a 2.8-6 times increased risk of pancreatic cancer.

A recent analysis by a team at Harvard's T.T. Chan School of Public Health found that new diabetes, a history of diabetes, or weight loss were all associated with an increased risk of pancreatic cancer.
the history of diabetes in 4 years, accompanied by weight loss of new diabetic patients, pancreatic cancer risk is 3.6-6.8 times that of normal people! The analysis by the Harvard team at 10.1001/jamaoncol.2020.2948 was based on follow-up data from more than 150,000 participants over nearly 30 years in two large-scale queue studies, the Renowned Nurses' Health Research (NHS) and the Health Professional Follow-up Study (HPFS), which identified some high-risk groups for pancreatic cancer.
study was published in JAMA Oncology.
although early detection and early treatment is the principle of cancer prevention, but such as pancreatic cancer, the rise of hidden, the incidence rate is not high cancer, screening for everyone is certainly not appropriate.
recommended by the U.S. Preventive Services Task Force (USPSTF), there is a clear objection to routine screening for pancreatic cancer in asymptomatic populations.
screening for all populations is not possible, what about high-risk groups? At present, the more clear high-risk groups of pancreatic cancer, including people with clear family history, associated genetic abnormalities and pancreatic cysts, their regular CT, MRI and other tests, can be found at an early stage of most pancreatic cancer, which brings very obvious benefits.
but only 15-20% of all patients were diagnosed with pancreatic cancer from people known to be at high risk, so they had to continue to look for potential risk groups for pancreatic cancer.
have found a link between pancreatic cancer and type 2 diabetes, with many people with pancreatic cancer developing short-term or persistent symptoms of diabetes.
, the pancreas and the islets in diabetes are not the same thing, but screening every diabetic is not realistic.
chinese adults alone, there are now more than 100 million people with diabetes, if you add in the number of patients diagnosed with two or three times the prediabetes ... If everyone were to pull a CT, the imaging doctor and the machine would definitely have to strike.
so it's not enough to simply look at the symptoms of diabetes, unless you're diagnosed with type 3c diabetes, which is clearly associated with pancreatic cancer.
what characteristics do you need to add to define high-risk groups? Some people think of the common weight loss in cancer patients.
the general diabetics are more likely to gain weight, but weight loss is more common in type 3c diabetes.
to test this hypothesis, it would be appropriate to use data from two Harvard School of Public Health"-level queue studies, the Harvard School of Public Health.
as of the time the study was collected, both queue studies had been going on for thirty or forty years, so the average follow-up time for subjects was more than 30 years.
more than 1,100 cases of pancreatic cancer were diagnosed during follow-up time, equivalent to a cumulative incidence rate of 0.7 percent, slightly lower than the U.S. historical data, according to the study's more than 150,000 subjects.
combined with the diabetes diagnosis and weight changes reported by the subjects, the team calculated the association between pancreatic cancer and both.
diabetes, which is indeed a risk factor associated with pancreatic cancer, " he said.
Diabetes history of less than 4 years, that is, new diabetes, is associated with a 2.97 times higher risk of pancreatic cancer in patients, while the risk of long-term diabetes is slightly lower (4-10 years, HR 2.25; more than 10 years, HR 2.07).
the relationship between recent weight loss and pancreatic cancer risk was less pronounced, with only a recent weight loss of more than 8 pounds (about 3.6 kg) associated with a 92% increase in the risk of pancreatic cancer.
but when you add up recent weight loss and new diabetes, the risk of pancreatic cancer is clear.
The pancreatic cancer incidence team, based on the patient's age, BMI, and other characteristics, divided two groups based on the weight loss of new diabetic patients: if the patient lost 1-8 pounds, it was associated with a 3.61 times higher risk of pancreatic cancer than normal, and if the risk of losing more than 8 pounds, the associated risk soared to 6.75 times! Even at BMI, the high-risk group remained largely unchanged.
data also showed that even in patients with long-term diabetes, losing more than 8 pounds was associated with a significant increased risk of pancreatic cancer.
relatively high risk scenarios include those with a baseline BMI of no more than 25, i.e. diabetics who are not overweight/obese, and "unexplained" patients with weight loss unrelated to exercise and dietary reasons. The
team also analyzed the history of diabetics and changes in weight over their lifetimes, and found that pancreatic cancer patients in long-term diabetes patients were generally relatively obese at first and lost weight after cancer, while those with new diabetes had relatively thin initial weight and showed a thin-fat-thin change.
trend is obvious in general, this analysis found that the new incidence of diabetes and recent weight loss population, is likely to be a large number of high-risk groups of pancreatic cancer.
because of the limitations of the cohort study, the team also said that the real benefits of pancreatic cancer screening for this group of people will have to be confirmed by clinical trials.
but the advice of the odd pastry is that "sugar friends" really don't have to wait for the final hammer of the experiment.
the burden of weight measurement much lower than daily self-testing of blood sugar? On the weight change more heart, perhaps can be the cancer king stopped early, this is absolutely worth ah.
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