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    Home > Active Ingredient News > Infection > JAMA Ophthalmol: Will the mother's infection with COVID-19 affect the eye health of the fetus?

    JAMA Ophthalmol: Will the mother's infection with COVID-19 affect the eye health of the fetus?

    • Last Update: 2021-04-16
    • Source: Internet
    • Author: User
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    Vertical transmission is one of the most serious complications of viral diseases during pregnancy.


    A study evaluated 38 pregnant women infected with COVID-19 and found that the new coronavirus is not associated with increased morbidity and mortality or maternal transmission to newborns.
    However, French and Chinese researchers have reported 3 cases of vertical transmission.
    Infection with COVID-19 Regarding the ophthalmological findings of newborns, no studies related to SARS-CoV-2 infection have been published so far.
    Since congenital viral infections such as cytomegalovirus and Zika virus can cause devastating effects on the eyes of newborns, it is important to determine whether SARS-CoV-2 can also cause eye manifestations in newborns.
    Regarding the ophthalmological findings of neonates, no studies related to SARS-CoV-2 infection have been published so far.
    Since congenital viral infections such as cytomegalovirus and Zika virus can have devastating consequences for newborns’ eyes, it is important to determine whether SARS-CoV-2 can also cause neonatal eye manifestations.
    Recently, in order to determine whether exposure to SARS-CoV-2 is related to the prognosis of neonatal eyes, a series of reports were carried out.
    The research results were published in the journal JAMA Ophthalmol.
    JAMAIn this case series, newborns from three different maternity hospitals in São Paulo, Brazil were registered from April to November 2020.
    The diagnosis of COVID-19 in mothers and newborns is based on real-time reverse transcription polymerase chain reaction, using oral, nasopharyngeal swab sample materials; IgM seropositivity is also considered a diagnostic test for the mother.
    If the newborn has any other evidence of congenital infection, it is excluded.
    All babies underwent external visual examination and indirect ophthalmoscope examination of both eyes.
    In this case series, newborns from three different maternity hospitals in São Paulo, Brazil were registered from April to November 2020.
    The diagnosis of COVID-19 in mothers and newborns is based on the real-time reverse transcription polymerase chain reaction method, using oral, nasopharyngeal swab sample materials; the diagnosis of IgM seropositivity is also considered a diagnostic test for the mother.
    If the newborn has any other evidence of congenital infection, it is excluded.
    All babies underwent external visual examination and indirect ophthalmoscope examination of both eyes.
    A total of 165 newborns were evaluated (the age range at the time of examination was 1 to 18 days).
    Among them, there were 123 full-term infants (74.
    5%) and 42 premature infants (25.
    4%).
    When COVID-19 tests positive, the gestational age of pregnant women ranges from week 1 to week 40.
    6 newborns (3.
    6%) were positive for SARS-CoV-2 polymerase chain reaction.
    One newborn was positive within 18 days (horizontal transmission), and 5 newborns were positive on the first day of birth (possibly vertical transmission) with no eye abnormalities.
    Among the neonates with negative results, 1 had venous congestion and tortuous vessels , 7 had intraretinal hemorrhage, and 2 were diagnosed with retinopathy of prematurity.
    A total of 165 newborns were evaluated (the age range at the time of examination was 1 to 18 days).
    Among them, there were 123 full-term infants (74.
    5%) and 42 premature infants (25.
    4%).
    When COVID-19 tests positive, the gestational age of pregnant women ranges from week 1 to week 40.
    6 newborns (3.
    6%) were positive for SARS-CoV-2 polymerase chain reaction.
    One newborn was positive within 18 days (horizontal transmission), and 5 newborns were positive on the first day of birth (possibly vertical transmission) with no eye abnormalities.
    Among the neonates with negative results, 1 had venous congestion and tortuous vessels , 7 had intraretinal hemorrhage, and 2 were diagnosed with retinopathy of prematurity.
    6 newborns (3.
    6%) were positive for SARS-CoV-2 polymerase chain reaction.
    One newborn was positive within 18 days (horizontal transmission), and 5 newborns were positive on the first day of birth (possibly vertical transmission) with no eye abnormalities.
    Among the neonates with negative results, 1 had venous congestion and tortuous vessels , 7 had intraretinal hemorrhage, and 2 were diagnosed with retinopathy of prematurity.
    6 newborns (3.
    6%) were positive for SARS-CoV-2 polymerase chain reaction.
    One newborn was positive within 18 days (horizontal transmission), and 5 newborns were positive on the first day of birth (possibly vertical transmission) with no eye abnormalities.
    Among the neonates with negative results, 1 had venous congestion and tortuous vessels , 7 had intraretinal hemorrhage, and 2 were diagnosed with retinopathy of prematurity.
    Blood vesselCharacteristics of COVID-19 infection in newborns Characteristics of COVID-19 infection in newborns Characteristics of COVID-19 infection in newbornsCharacteristics of newborns with abnormal eye exposure Characteristics of newborns with abnormal eye exposure Characteristics of newborns with abnormal eye exposure Characteristics of newborns with abnormal eye exposure Although the World Health Organization has not reported evidence of vertical transmission during the third trimester of pregnancy, this study shows a possibility Different situations.
    In addition, a recent publication reported a possible case of mother-to-child transmission occurring at 35 weeks of gestation.
    Although the World Health Organization has not reported evidence of vertical transmission during the third trimester of pregnancy, this study shows a possible different situation.
    In addition, a recent publication reported a possible case of mother-to-child transmission occurring at 35 weeks of gestation.
    Although the World Health Organization has not reported evidence of vertical transmission during the third trimester of pregnancy, this study shows a possible different situation.
    In addition, a recent publication reported a possible case of mother-to-child transmission occurring at 35 weeks of gestation.
    Although the World Health Organization has not reported evidence of vertical transmission during the third trimester of pregnancy, this study shows a possible different situation.
    In addition, a recent publication reported a possible case of mother-to-child transmission occurring at 35 weeks of gestation.
    Given that the appearance in this study is consistent with postpartum hemorrhage, it is difficult to judge whether retinal hemorrhage is secondary to COVID-19 or accidental, because the rate found in this study (4.
    2%[7/165]) is in the published cross-sectional report (6.
    7%).
    In addition, 2 newborns in the study had retinopathy of prematurity.
    This means that the incidence of retinopathy in infants weighing less than 1250 grams at birth is 333%, which is also in line with the expected incidence of retinopathy of prematurity in the unborn population of COVID-19.
    Given that the appearance in this study is consistent with postpartum hemorrhage, it is difficult to judge whether retinal hemorrhage is secondary to COVID-19 or accidental, because the rate found in this study (4.
    2%[7/165]) is in the published cross-sectional report (6.
    7%).
    In addition, 2 newborns in the study had retinopathy of prematurity.
    This means that the incidence of retinopathy in infants weighing less than 1250 grams at birth is 333%, which is also in line with the expected incidence of retinopathy of prematurity in the unborn population of COVID-19.
    Given that the appearance in this study is consistent with postpartum hemorrhage, it is difficult to judge whether retinal hemorrhage is secondary to COVID-19 or accidental, because the rate found in this study (4.
    2%[7/165]) is in the published cross-sectional report (6.
    7%).
    In addition, 2 newborns in the study had retinopathy of prematurity.
    This means that the incidence of retinopathy in infants weighing less than 1250 grams at birth is 333%, which is also in line with the expected incidence of retinopathy of prematurity in the unborn population of COVID-19.
    Given that the appearance in this study is consistent with postpartum hemorrhage, it is difficult to judge whether retinal hemorrhage is secondary to COVID-19 or accidental, because the rate found in this study (4.
    2%[7/165]) is in the published cross-sectional report (6.
    7%).
    In addition, 2 newborns in the study had retinopathy of prematurity.
    This means that the incidence of retinopathy in infants weighing less than 1250 grams at birth is 333%, which is also in line with the expected incidence of retinopathy of prematurity in the unborn population of COVID-19.
    In short, the rate of eye abnormalities found in this study is very low, and may be within the expected range of findings without COVID-19, which indicates that the risk of neonatal eye abnormalities of COVID-19 mothers is not moderate.
    Or increase in height.
    In order to rule out a low-risk increase, additional controls and larger studies are needed, including standardized imaging (fundus images and optical coherence tomography) and standardization by ophthalmologists.
    In short,The rate of eye abnormalities found in this study is very low and may be within the expected range of findings without COVID-19, which indicates that the risk of neonatal eye abnormalities of COVID-19 mothers is not moderate or high increase.
    In order to rule out a low-risk increase, additional controls and larger studies are needed, including standardized imaging (fundus images and optical coherence tomography) and standardization by ophthalmologists.
    In short, the rate of eye abnormalities found in this study is very low, and may be within the expected range of findings without COVID-19, which indicates that the risk of neonatal eye abnormalities of COVID-19 mothers is not moderate.
    Or increase in height.
    In order to rule out a low-risk increase, additional controls and larger studies are needed, including standardized imaging (fundus images and optical coherence tomography) and standardization by ophthalmologists.
    In short,the rate of eye abnormalities found in this study is very low, and may be within the expected range of findings without COVID-19, which indicates that the risk of neonatal eye abnormalities of COVID-19 mothers is not moderate.
    Or increase in height.
    In order to rule out a low-risk increase, additional controls and larger studies are needed, including standardized imaging (fundus images and optical coherence tomography) and standardization by ophthalmologists.
    The rate of eye abnormalities found in this study is very low and may be within the expected range of findings without COVID-19, which indicates that the risk of neonatal eye abnormalities of COVID-19 mothers is not moderate or high increase.
    The rate of eye abnormalities found in this study is very low and may be within the expected range of findings without COVID-19, which indicates that the risk of neonatal eye abnormalities of COVID-19 mothers is not moderate or high increase.
    Despite the need for more data, the vertical transmission of SARS-CoV-2 seems possible and should be a cause for concern , especially in asymptomatic cases, which is very common in the population, and even when the congenital infection rate is very low.
    Under the circumstances, it may also bring a huge burden to patients and the health care system.
    Considering the non-invasive nature of fundus examinations, retinal changes should be further studied in prospective studies to understand its possible application in the diagnosis and treatment of COVID-19.
    Despite the need for more data, the vertical transmission of SARS-CoV-2 seems possible and should be a cause for concern , especially in asymptomatic cases, which is very common in the population, and even when the congenital infection rate is very low.
    Under the circumstances, it may also bring a huge burden to patients and the health care system.
    Considering the non-invasive nature of fundus examinations, retinal changes should be further studied in prospective studies to understand its possible application in the diagnosis and treatment of COVID-19.
    Despite the need for more data, the vertical transmission of SARS-CoV-2 seems possible and should be a cause for concern, especially in asymptomatic cases, which is very common in the population, and even when the congenital infection rate is very low.
    Under the circumstances, it may also bring a huge burden to patients and the health care system.
    Considering the non-invasive nature of fundus examinations, retinal changes should be further studied in prospective studies to understand its possible application in the diagnosis and treatment of COVID-19.
    Despite the need for more data, the vertical transmission of SARS-CoV-2 seems possible and should be a cause for concern, especially in asymptomatic cases, which is very common in the population, and even when the congenital infection rate is very low.
    Under the circumstances, it may also bring a huge burden to patients and the health care system.
    Considering the non-invasive nature of fundus examinations, retinal changes should be further studied in prospective studies to understand its possible application in the diagnosis and treatment of COVID-19.
    Although more data is needed, the vertical transmission of SARS-CoV-2 seems to be possible and should be concerned.
    Although more data is needed, the vertical transmission of SARS-CoV-2 seems to be possible and should betaken into consideration.
    The non-invasiveness of fundus examination should be further studied in prospective studies to understand its possible application in the diagnosis and treatment of COVID-19.
    Considering the non-invasive nature of fundus examinations, retinal changes should be further studied in prospective studies to understand its possible application in the diagnosis and treatment of COVID-19.
    Kiappe OP, Santos da Cruz NF, Rosa PAC, Arrais L, Bueno de Moraes NS.
    Ocular Assessments of a Series of Newborns Gestationally Exposed to Maternal COVID-19 Infection.
      JAMA Ophthalmol.
     Published online April 07, 2021.
    com/journals/jamaophthalmology/fullarticle/2778288" target="_blank" rel="noopener">doi:10.
    1001/jamaophthalmol .
    2021.
    1088com/journals/jamaophthalmology/fullarticle/2778288" target="_blank" rel="noopener"> doi:10.
    1001/jamaophthalmol.
    2021.
    1088

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