JAMA Pediatr: Low-dose prednisolone administered during upper respiratory tract infection does not reduce the risk of recurrence in children with hormone-sensitive nephropathy

Hormone Sensitive Nephrotic Syndrome (SSNS) is the most common glomerular disease in children , with an incidence of approximately 2 cases per 100,000 children, but the incidence in South Asian children is 6 times that of the general population
.

More than 80% of children with SSNS will relapse.

In previous small-scale studies of thrombotic infections in children, low-dose prednisolone daily for 5 to 7 days when upper respiratory tract infections occur in children with SSNS can reduce the risk of recurrence of kidney disease

Primary endpoint difference

The primary endpoint differences primary endpoint differences

Studies have found that the use of low-dose prednisolone during upper respiratory tract infections in children with recurrent hormone-sensitive nephrotic syndrome does not reduce the risk of recurrence of nephrotic syndrome
.

Low-dose prednisolone used during upper respiratory tract infections in children with recurrent hormone-sensitive nephrotic syndrome does not reduce the risk of recurrence of nephrotic syndrome Low-dose prednisone used during upper respiratory tract infections in children with recurrent hormone-sensitive nephrotic syndrome Long will not reduce the risk of recurrence of nephrotic syndrome.

Original Source:
Evaluation of Daily Low-Dose Prednisolone During Upper Respiratory Tract Infection to Prevent Relapse in Children With Relapsing Steroid-Sensitive Nephrotic Syndrome The PREDNOS 2 Randomized Clinical Trial.
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