JAMA Psychiatry: Eating disorder will change the brain's reward response

Eating disorders are serious mental illnesses that can lead to serious complications, including death

Eating disorders are serious mental illnesses that can lead to serious complications, including death

 Eating disorder is a serious mental disorder with a high mortality rate

 Eating disorder is a serious mental disorder with a high mortality rate

Published in JAMA on Psychiatry JAMA study by research made now, binge eating and other eating disorders reward behavior change and food intake during the reaction of the brain control loop, binge eating and other eating disorder behavior will change and the brain's reward response process Food intake control circuit, which may change the food intake control circuit and strengthen the individual's eating disorder behavior

In this study, Guido Frank, MD, of the University of California, San Diego, and colleagues wanted to understand how behaviors in the spectrum of eating disorders affect the reward response in the brain, how changes in reward response change the food intake control circuit, and if these changes Will strengthen eating disorders

In this study, Guido Frank, MD, of the University of California, San Diego, and colleagues wanted to understand how behaviors in the spectrum of eating disorders affect the reward response in the brain, how changes in reward response change the food intake control circuit, and if these changes Will strengthen eating disorders

 The study recruited 197 people with different eating disorders (including anorexia nervosa, bulimia nervosa, binge eating disorder, and other specific feeding and eating disorders) and different body mass index (BMI) related to eating disorder behaviors Of women, and 120 women without eating disorders

The researchers analyzed a brain reward response called "prediction error," a signal transmission process related to dopamine that measures the degree of deviation from expectations or the degree of surprise when a person receives an unexpected stimulus

 Researchers found that in the group of women without eating disorders, there was no significant correlation between BMI, eating disorder behaviors, and brain reward responses

 Correlation between regional prediction error response, BMI, binge eating frequency and EDI-3 binge eating disorder score

 Correlation between regional prediction error response, BMI, binge eating frequency and EDI-3 binge eating disorder score

Effective connection diagram of each study group

Effective connection diagram of each study group

These results indicate that for women suffering from eating disorders, eating disorder behaviors and excessive weight loss or weight gain can regulate the brain's response to dopamine-related reward circuits, change the brain circuits related to food intake control, and may strengthen eating disorder behaviors

For example, women with anorexia nervosa, restricted food intake, and low BMI have higher predictive error responses

"This study provides a model of how behavioral characteristics contribute to changes in eating problems and BMI, as well as how eating disorder behavior, anxiety, mood, and brain neurobiology interact to strengthen the vicious circle of eating disorders and make rehabilitation very important.

 In general, this study shows that behavioral characteristics, including food intake behavior, contribute to the maintenance and development of eating disorders by regulating a person's internal reward response and changing the food intake control circuit

 References : Frank GKW, Shott ME, Stoddard J, Swindle S, Pryor TL.
Association of Brain Reward Response With Body Mass Index and Ventral Striatal-Hypothalamic Circuitry Among Young Women With Eating Disorders.
JAMA Psychiatry.
 Published online June 30, 2021.
doi:10.
1001/jamapsychiatry.
2021.
1580  Frank GKW, Shott ME, Stoddard J, Swindle S, Pryor TL.
Association of Brain Reward Response With Body Mass Index and Ventral Striatal-Hypothalamic Circuitry Among Young Women With Eating Disorders.
JAMA Psychiatry.
JAMA Psychiatry.
 Published online June 30, 2021.
doi:10.
1001/jamapsychiatry.
2021.
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