"JAMA" sub-issue: drinking coffee can reduce colorectal cancer deaths and prolong survival

On September 17, 2020, Mayo Medical Center, Dana-Farber Cancer Institute and other top international medical research institutions cooperated to publish research papers in the top medical journal "JAMA Oncology"

And among those with metastatic colorectal cancer, those who drank 2-3 cups of coffee a day had longer overall survival and a lower risk of cancer progression, while those who drank 4 cups of coffee a day had a greater benefit

Several studies over the past few years have shown that drinking coffee regularly has many health benefits

Drinking more coffee may reduce liver cancer mortality

In August 2020, a number of Australian research institutions collaborated to publish a paper in the journal "Alimentary Pharmacology and Therapeutics[1]"

Analysis of the Global Burden of Disease dataset showed that with increasing coffee intake, liver cancer-related deaths increased globally

Specifically, if everyone in the world drank at least two cups of coffee a day, the number of deaths from liver cancer would be reduced by more than 450,000 globally, and if everyone in the world drank at least 4 cups of coffee a day, the number of deaths from liver cancer would be reduced by more than 720,000

Drinking more coffee may reduce the risk of many chronic diseases

On July 23, 2020, the New England Journal of Medicine (NEJM), one of the four major medical journals, published a review article entitled "Coffee, Caffeine and Health [2]"

The paper noted that there is substantial evidence that drinking coffee does not increase the risk of cardiovascular disease and cancer, and that drinking 3 to 5 cups of coffee a day is associated with a lower risk of several chronic diseases

Drinking more coffee may prolong life in colorectal cancer patients

On September 17, 2020, the Mayo Medical Center, Dana-Farber Cancer Institute and other top international medical research institutions cooperated to publish the title "Coffee Intake and Advanced Stage or Metastasis" in the top medical journal "JAMA Oncology".

The team further analyzed observational data from a large clinical trial of colorectal cancer patients and found that among 1,171 patients with metastatic colorectal cancer who were treated, those who drank 2-3 cups of coffee a day had longer overall survival and less cancer.

The risk of disease progression was lower, and patients who drank 4 cups of coffee a day benefited more

The paper's data come from a phase III clinical trial comparing the addition of cetuximab and/or bevacizumab to standard chemotherapy in patients with previously untreated locally advanced or metastatic colorectal cancer

As part of the clinical trial, the researchers asked these patients about their dietary intake, including coffee intake, via a questionnaire

Data were collected between October 27, 2005, and January 18, 2018, and the researchers correlated the data with information on cancer progression after treatment

Several compounds in coffee have been previously known to have antioxidant, anti-inflammatory and potential anti-cancer properties, and epidemiological studies have also found that increased coffee intake is associated with survival in patients with advanced colorectal cancer, but it is not yet known.

Evidence for the association between caffeine deficiency and survival in patients with metastatic disease

The researchers found that patients who drank 2-3 cups of coffee a day lived longer overall and had a lower risk of cancer progression compared with patients who drank no coffee, while those who drank 4 cups a day benefited more

Coffee intake and overall survival in patients with colorectal cancer

Association between coffee intake and progression-free survival in patients with colorectal cancer

The findings could establish a link between coffee drinking and a reduced risk of cancer and death in people with colorectal cancer, but the data were insufficient to establish cause and effect, the researchers said
.

So it's too early to suggest drinking more coffee as a potential treatment for colorectal cancer, but this study shows that drinking coffee is not only harmless, it may have many benefits
.

In conclusion, the study further supports the importance of diet and other modifiable factors in the management of colorectal cancer patients, says Kimmie Ng, the study's corresponding author
.

Further research is now needed to determine whether there is a causal relationship between coffee consumption and improved outcomes in patients with colorectal cancer, and which substances in coffee are responsible for this benefit
.

refer to:

1.
https://onlinelibrary.
wiley.
com/doi/full/10.
1111/apt.
16020
2.
https:// 2.
https://jamanetwork.
com/ journals/jamaoncology/article-abstract/2770262

(Source: Internet, reference only)