JAMA Sub-Journal: A cohort study of 1.6 million people confirmed that the mother’s miscarriage and stillbirth history are related to the offspring’s congenital heart disease!

Congenital heart disease (CHD) is the most common congenital abnormal disease, with a global incidence rate of 9-18 per 1,000 live births

Congenital heart disease (CHD) is the most common congenital abnormal disease, with a global incidence rate of 9-18 per 1,000 live births

Screening

This population-based cohort study included only children born between January 1, 1977 and December 31, 2016, as determined by the Danish National Health Registry

diagnosis

The results showed that among the 1,642,534 children included, 246669 (15.

The HRs of CHD of the offspring with a history of SA disease were 1.

The relationship between the history of maternal SA or stillbirth and CHD of the offspring

The relationship between the history of maternal SA or stillbirth and CHD of the offspring

With 2 diabetes in pregnant women SA history and CHD association between

With 2 diabetes in pregnant women SA history and CHD association between

These findings indicate that the offspring of mothers who had previously had SA or stillbirth (especially multiple) or pre-pregnancy type 2 diabetes have a higher risk of being diagnosed with CHD

The offspring of mothers who have previously had SA or stillbirth (especially multiple) or type 2 diabetes before pregnancy are at higher risk of being diagnosed with CHD

This result cohort studies have demonstrated mother of SA or stillbirths children were diagnosed with higher CHD risk

Ji H, Liang H, Yu Y, et al.
Association of Maternal History of Spontaneous Abortion and Stillbirth With Risk of Congenital Heart Disease in Offspring of Women With vs Without Type 2 Diabetes.
JAMA Netw Open.
JAMA2021;4(11): e2133805.
doi:10.
1001/jamanetworkopen.
2021.
33805 doi:10.
1001/jamanetworkopen.
2021.
33805

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