JAMA Sub-Journal: Neurofilament (NfL) levels can predict the risk of retinopathy and neurodevelopmental disorders in preterm infants in the future

Pixabay.

Pixabay.

The brain damage biomarkers neurofilament (NfL) and glial fibrillary acidic protein (GFAP) are specific peptides that reflect the damage of nerve axons and astrocytes in the brain.

There are few data on NfL in premature infants.

It is estimated that 15 million babies are born before 37 weeks of pregnancy each year.

Recently, studies have explored the longitudinal serum levels of NfL and GFAP in preterm infants within 15 weeks after birth, and explored the possible links between these biomarkers and neonatal morbidity and neurodevelopmental outcomes at 2 years of age.

This cohort study used data from 3 clinical studies, including 221 infants born before 32 weeks of gestational age (GA) from 1999 to 2015; the neurodevelopmental outcome of 120 infants was evaluated.

This cohort study used data from 3 clinical studies, including 221 infants born before 32 weeks of gestational age (GA) from 1999 to 2015; the neurodevelopmental outcome of 120 infants was evaluated.

The main outcomes of the study were serum NfL and GFAP levels at 2 years of age, retinopathy of prematurity (ROP), intraventricular hemorrhage, infant development grade II and III Bayley scales, using odds ratio (OR), receiver operating characteristic curve ( ROC) analysis.

221 babies (108 [48.

Correlation between BSID II and BSID III and neurofilament light area under the curve of 2 to 4 weeks

Correlation between nerve filament light area under the curve in 2 to 4 weeks and BSID II and BSID III Correlation between nerve filament light area under the curve in 2 to 4 weeks and BSID II and BSID III 2 to 4 week nerve fiber area under the curve and BSID II and BSID Correlation of III Correlation betweenneurofilament area under the curveof2 to 4 weeks and BSID II and BSID III

The study results suggest that early postpartum birth and GFAP biomarker NfL elevated levels of neuronal injury , NfL still maintain a high level of at least one month after birth.

The study results suggest that early postpartum birth and GFAP biomarker NfL elevated levels of neuronal injury , NfL still maintain a high level of at least one month after birth.

In simple terms, high NfL levels in the first week of premature infants are associated with ROP and neurodevelopmental dysplasia at the age of 2 years.

References: Sjöbom U, Hellström W, Löfqvist C, et al.
Analysis of Brain Injury Biomarker Neurofilament Light and Neurodevelopmental Outcomes and Retinopathy of Prematurity Among Preterm Infants.
JAMA Netw Open.
2021;4(4):e214138.
com/journals/jamanetworkopen/fullarticle/2778143" target="_blank" rel="noopener">doi:10.
1001/ jamanetworkopen.
2021.
4138 References: Sjöbom U, Hellström W, Löfqvist C, et al.
Analysis of Brain Injury Biomarker Neurofilament Light and Neurodevelopmental Outcomes and Retinopathy of Prematurity Among Preterm Infants.
JAMA Netw Open.
2021;4(4):e214138.
com/journals/jamanetworkopen/fullarticle/2778143" target="_blank" rel="noopener">doi :10.
1001/jamanetworkopen.
2021.
4138 References:Sjöbom U, Hellström W, Löfqvist C, et al.
Analysis of Brain Injury Biomarker Neurofilament Light and Neurodevelopmental Outcomes and Retinopathy of Prematurity Among Preterm Infants.
  JAMA Netw Open.
 2021;4(4):e214138.
com/journals/jamanetworkopen/fullarticle/2778143" target="_blank" rel="noopener">doi:10.
1001/jamanetworkopen.
2021.
4138 Sjöbom U, Hellström W, Löfqvist C, et al.
Analysis of Brain Injury Biomarker Neurofilament Light and Neurodevelopmental Outcomes and Retinopathy of Prematurity Among Preterm Infants.
  JAMA Netw Open.
 2021;4(4):e214138.
com/journals/jamanetworkopen/fullarticle/2778143" target="_blank" rel="noopener">doi:10.
1001/jamanetworkopen.
2021.
4138com/journals/jamanetworkopen/fullarticle/2778143" target="_blank" rel="noopener"> doi:10.
1001/jamanetworkopen.
2021.
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