JAMA Sub-Journal: Rest assured!

Cervical cancer is one of the most common cancers in women worldwide
.

In 2012 alone, there were 630,000 new cases of cancer related to human papillomavirus (HPV), of which 530,000 (84%) were diagnosed as cervical cancer

In 2012 alone, there were 630,000 new cases of cancer related to human papillomavirus (HPV), of which 530,000 (84%) were diagnosed as cervical cancer

Diagnostic immunity

To this end, as of 2019, 124 countries have included HPV vaccination policies into their national immunization plans
.

Since June 2016, the Korean Agency for Disease Control and Prevention has also launched a two-dose plan for bivalent or quadrivalent HPV vaccine for adolescent girls aged 12-13

Prevention In the first year of the implementation of the plan, the coverage rate of the first dose of HPV vaccine for school-age women was 61.

Although the HPV vaccine is widely used worldwide, people have always been concerned about the safety of HPV vaccination, and it has been confirmed that concerns about serious adverse events related to the vaccine have weakened the public's confidence in immunization
.

For this reason, the large sample data of Asian population published in the latest "British Medical Journal" (BMJ) earlier this year showed that HPV vaccination is safe and did not produce serious adverse reactions

For this reason, the large sample data of Asian population published in the latest "British Medical Journal" (BMJ) earlier this year showed that HPV vaccination is safe and did not produce serious adverse reactions

JAMA

This cohort study of type-specific cervical HPV testing was conducted at a large comprehensive health center for adolescents in New York City from October 2007 to September 2019
.

Participants data for 12 years after receiving HPV vaccination were obtained

Infect

In the end, a total of 1453 participants, with a mean age (SD) of 18.
2 (1.
4) years at baseline, were included in the cohort (African Americans without Hispanics, 515 [35.
4%] participants; those with Hispanics African-Americans, 218 [15.
0%] participants; Hispanics without race reports, 637 (43.
8%) participants)
.

About half (694 [47.

The results showed that the age-adjusted detection rate of quadrivalent vaccine types (HPV-6, HPV-11, HPV-16, and HPV-18) and related types (HPV-31 and HPV-45) decreased year by year
.

Specifically, the infection rate dropped from 9.

Specifically, the infection rate dropped from 9.

After vaccination, age-standardized prevalence of cervical and anal HPV by year

In contrast, the detection rates of non-vaccine high-risk cervical HPV (OR=1.
08; 95%CI: 1.
04-1.
13) and anal HPV types (OR=1.
11; 95%CI: 1.
05-1.
17) have been increasing year by year.
Non-vaccine HPV-56 and HPV-68 have the greatest impact
.

In contrast, the detection rates of non-vaccine high-risk cervical HPV (OR=1.
08; 95%CI: 1.
04-1.
13) and anal HPV types (OR=1.
11; 95%CI: 1.
05-1.
17) have been increasing year by year.
Non-vaccine HPV-56 and HPV-68 have the greatest impact
.
In contrast, the detection rates of non-vaccine high-risk cervical HPV (OR=1.
08; 95%CI: 1.
04-1.
13) and anal HPV types (OR=1.
11; 95%CI: 1.
05-1.
17) have been increasing year by year.
Non-vaccine HPV-56 and HPV-68 have the greatest impact
.

It can be seen that after the quadrivalent HPV vaccine, the infection rate of high-risk HPV subtypes covered by the vaccine and cross-protection is decreasing year by year; in sharp contrast, the infection rate of non-vaccine-covered HPV subtypes is increasing
.

It can be seen that after the quadrivalent HPV vaccine, the infection rate of high-risk HPV subtypes covered by the vaccine and cross-protection is decreasing year by year; in sharp contrast, the infection rate of HPV subtypes not covered by the vaccine is climbing
.
It can be seen that after the quadrivalent HPV vaccine, the infection rate of high-risk HPV subtypes covered by the vaccine and cross-protection is decreasing year by year; in sharp contrast, the infection rate of non-vaccine-covered HPV subtypes is increasing
.

 

references:

Incidence and Types of Human Papillomavirus Infections in Adolescent Girls and Young Women Immunized With the Human Papillomavirus Vaccine.
JAMA Netw Open, doi: 10.
1001/jamanetworkopen.
2021.
21893

Incidence and Types of Human Papillomavirus Infections in Adolescent Girls and Young Women Immunized With the Human Papillomavirus Vaccine.
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