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Obesity (generally defined as body mass index BMI> 30) has been regarded as a chronic disease, with an increasing incidence worldwide, which has led to many health problems to a large extent.
Increased body fat is an important risk factor for many serious diseases, including heart disease, metabolic syndrome and even stroke.
In particular, a meta-analysis of 230 cohort studies including more than 30 million people found that both obesity and overweight are associated with an increased risk of death from all causes.
At the same time, it is currently known that the increase in BMI is also related to the increased risk of multiple cancer types.
The mechanisms leading to higher cancer morbidity and mortality may include changes in sex hormone metabolism, insulin and insulin-like growth factor levels, and adipokines pathways.
JAMA diagnosis
The researchers searched the PubMed, Cochrane, and EMBASE databases and selected studies that included the use of standard BMI categories and cancer to report the prognosis of obese patients.
The main result of the study is the overall survival rate of cancer patients, with or without obesity.
Compared with non-obese patients, obese cancer patients increased the risk of all-cause death by 14% (HR=1.
Specifically, obesity has different risks of all-cause death and cancer-specific risks caused by different cancer types.
Obesity increases the risk of all-cause death from breast cancer , colorectal cancer , pancreatic cancer , and endometrial cancer by 26%, 22%, 36%, and 20%, respectively; but it also reduces the risk of all-cause death from lung cancer, melanoma, and kidney cancer by 14 %, 26% and 22%.
In terms of cancer-specific mortality risk, obesity still has mixed performance.
At the same time, the overall risk of recurrence in obese cancer patients has also increased by 13%.
The overall risk of recurrence in obese cancer patients also increased by 13%.
Obesity is associated with a higher overall mortality rate among cancer patients.
references:
Petrelli F, et al.
com/journals/jamanetworkopen/fullarticle/2777839" target="_blank" rel="noopener">Association of Obesity With Survival Outcomes in Patients With Cancer: A Systematic Review and Meta-analysis.
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