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According to estimates by the World Health Organization, there are 422 million adults living with diabetes worldwide , and its prevalence (8.
According to estimates by the World Health Organization, there are 422 million adults living with diabetes worldwide , and its prevalence (8.
Pixabay.
Pixabay.
Current PDN treatments include neuropathic pain drugs such as gabapentin, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, opioids, and topical solutions.
The use of spinal cord stimulation (SCS) equipment for non-pharmacological PDN treatment was first reported in 1996.
This prospective, multi-center, open-label randomized clinical trial of SENZA-PDN compares traditional medical management (CMM) and 10 kHz SCS+CMM.
Use 10cm visual analog scale (VAS) to measure pain relief over time
Use 10cm visual analog scale (VAS) to measure pain relief over timeThe pre-set primary endpoint was the percentage of participants whose VAS pain was relieved by 50% or more at 3 months and the baseline neurological deficit did not worsen.
Among the 216 randomized patients, 136 (63.
5 of the 94 patients in the CMM group (5%) reached the primary endpoint of the intention-to-treat population, and 75 of the 95 patients in the 10 kHz SCS+CMM group.
Changes in neurological assessment and pain quality
Changes in neurological assessment and pain qualityRegardless of the cause, chronic pain can negatively affect sleep quality.
Regardless of the cause, chronic pain can negatively affect sleep quality.
In short, high-frequency (10khz) SCS can safely and effectively treat patients with refractory PDN.
References: Petersen EA, Stauss TG, Scowcroft JA, et al.
Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy :A Randomized Clinical Trial .
JAMA Neurol.
Published online April 05, 2021.
com/journals/jamaneurology/fullarticle/2777806" target="_blank" rel="noopener">DOI: 10.
1001 / jamaneurol.
2021.
0538 Petersen EA, Stauss TG, The Scowcroft JA, et Al Effect of High-Frequency (kHz-10) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy.
: A Randomized Clinical Trial : .
JAMA Neurol.
.
Published Online April 05, 2021.
com/journals/jamaneurology/fullarticle/2777806" target="_blank" rel="noopener">doi:10.
1001/jamaneurol.
2021.
0538com/journals/jamaneurology/fullarticle/2777806" target="_blank" rel="noopener"> doi:10.
1001/jamaneurol.
2021.
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