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    Home > Biochemistry News > Biotechnology News > JAMA Sub-Journal: What are the consequences of discontinuing statins?

    JAMA Sub-Journal: What are the consequences of discontinuing statins?

    • Last Update: 2021-06-28
    • Source: Internet
    • Author: User
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    Atherosclerotic cardiovascular disease (ASCVD) is a major disease that causes death in the elderly and affects the quality of life
    .
    Statins can safely and effectively lower cholesterol, stabilize or even reverse plaque, and have become the cornerstone of anti-atherosclerosis and reducing the risk of cardiovascular disease

    .
    However, due to the general number of underlying diseases in the elderly, a common problem is the need to receive multiple drug treatments.
    In this part of patients, it may be possible to temporarily stop statins or reduce the dose of statins

    .

    Recently, a study published in JAMA Network Open, a sub-journal of JAMA, showed that for people 65 years and older, if statins are stopped, the risk of fatal and non-fatal cardiovascular disease may be higher
    .

    The researchers included 29047 residents ≥65 years of age from Italy who started taking statins, antihypertensive drugs, hypoglycemic drugs, and antihypertensive drugs without interruption from October 1, 2013 to January 31, 2015.
    Platelet medication

    .

    The research team followed them up to June 30, 2018, during which 5819 people (20.
    0%) stopped statins but maintained other treatments

    .
    Combining the information of patients who did not stop using statins or other drugs, the research team conducted a matched control analysis

    .

    The results found that compared with those who continued to take statins, patients who stopped taking statins had a 24% higher risk of hospitalization for heart failure (HR=1.
    24) and a 14% higher risk of other cardiovascular health problems ( HR=1.
    14), the likelihood of death from any cause is 15% higher (HR=1.
    15), and the likelihood of patients requiring emergency treatment is also increased by 12% (HR=1.
    12)

    .

    The American Heart Association recommends that patients who need statin therapy should start taking statins before the age of 75, and continue to use them if they can tolerate them after the age of 75
    .

    The "Chinese Expert Consensus on the Use of Statins in the Elderly with Dyslipidemia" also pointed out:

    Generally, the safety and tolerability of statins by the elderly are good
    .
    Age should not be an obstacle to the use of statins for the elderly (≥80 years old).
    It should be stratified according to the risk of cardiovascular disease, combined with physiological age, liver and kidney function, concomitant diseases, combined medication, life expectancy, etc.
    , and fully weighed and adjusted The pros and cons of lipid treatment, actively and steadily choose lipid-lowering drugs

    .
    After the use of statins to achieve blood lipids, long-term medication should be adhered to.
    The dose can be adjusted according to the blood lipid level or even different statins should be changed.
    If there is no special reason, the drug should not be discontinued

    .
    After stopping statins, blood lipids increased or even rebounded, which significantly increased cardiovascular events and mortality

    .

    Note: The original text has been deleted

    references:

    [1] Rea F, Biffi A, Ronco R, et al(2021).
    Cardiovascular Outcomes and Mortality Associated With Discontinuing Statins in Older Patients Receiving Polypharmacy.
    JAMA Netw Open.
    ;4(6):e2113186.
    doi:10.
    1001/jamanetworkopen.
    2021.
    13186

    [2] Odds for death, hospital care rise when statins are stopped.
    Retrieved JUNE 14, 2021, from https://medicalxpress.
    com/news/2021-06-odds-death-hospital-statins.
    html

    [3] 2015 Chinese expert consensus on the use of statins in the elderly with dyslipidemia released.
    Retrieved 2015-05-26, from https://news.
    medlive.
    cn/heart/info-progress/show-78900_129.
    html

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