JAMA Sub-Journal: What are the consequences of discontinuing statins? The cardiovascular outcome will be worse!

Atherosclerotic cardiovascular disease (ASCVD) is a major disease that causes death in the elderly and affects the quality of life

Recently, a study published in JAMA Network Open, a sub-journal of JAMA, showed that for people 65 years and older, if statins are stopped, the risk of fatal and non-fatal cardiovascular disease may be higher

The researchers included 29047 residents ≥65 years of age from Italy who started taking statins, antihypertensive drugs, hypoglycemic drugs, and antihypertensive drugs without interruption from October 1, 2013 to January 31, 2015.

The research team followed them up to June 30, 2018, during which 5819 people (20.

The results found that compared with those who continued to take statins, patients who stopped taking statins had a 24% higher risk of hospitalization for heart failure (HR=1.

The American Heart Association recommends that patients who need statin therapy should start taking statins before the age of 75, and continue to use them if they can tolerate them after the age of 75

The "Chinese Expert Consensus on the Use of Statins in the Elderly with Dyslipidemia" also pointed out:

Generally, the safety and tolerability of statins by the elderly are good

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references:

[1] Rea F, Biffi A, Ronco R, et al(2021).

[2] Odds for death, hospital care rise when statins are stopped.

[3] 2015 Chinese expert consensus on the use of statins in the elderly with dyslipidemia released.