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Hydroxymethylglutaryl-CoA reductase inhibitors (Statins, referred to as "HMG-CoA reductase inhibitors" or "statins") are a class of anti-hyperlipidemic drugs
Cholesterol Current research shows that because statins reduce cardiac vascular diseases role
Among them, hydroxymethylglutaryl-CoA reductase (3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase) is the rate-limiting enzyme in the synthesis process, which can catalyze the reduction of HMG-CoA to formaldehyde.
This step is a key step in the synthesis of endogenous cholesterol.
Lipid-lowering treatment for patients with dyslipidemia is helpful to the primary and secondary prevention of coronary heart disease and cardiovascular disease such as stroke .
In order to evaluate the clinical significance of stopping the use of statins while retaining other drugs in elderly patients receiving multi-drug therapy, experts from the National Center for Health Care Research and Drug Epidemiology of the University of Bicocca in Milan, Italy conducted related research.
In order to evaluate the clinical significance of stopping the use of statins while retaining other drugs in elderly patients receiving multi-drug therapy, experts from the National Center for Health Care Research and Drug Epidemiology of the University of Bicocca in Milan, Italy conducted related research.
This retrospective, population-based cohort study included 29047 residents 65 years of age or older in Lombardy, Italy , who received statins, antihypertensive drugs, antidiabetics , and antidiabetics from 2013.
Test procedure
Test procedureThe researchers followed the cohort members to identify those who stopped using statins
The researchers followed the cohort members to identify those who stopped using statins
The final inclusion included 29047 patients (mean [SD] age, 76.
The average ( SD ) age of the drug withdrawal group was 76.
The relationship between stopping statins and cardiovascular risk, hospitalization risk, all-cause mortality, and hospitalization for any reason
The relationship between stopping statins and cardiovascular risk, hospitalization risk, all-cause mortality, and hospitalization for any reasonIn general, compared with the maintenance group, patients in the discontinuation group were due to heart failure (HR=1.
In general, compared with the maintenance group, patients in the discontinuation group were due to heart failure (HR=1.
It can be seen that discontinuation of statins may be related to the increased long-term risk of life-threatening cardiovascular outcomes
references:
references:Cardiovascular Outcomes and Mortality Associated With Discontinuing Statins in Older Patients Receiving Polypharmacy.
Cardiovascular Outcomes and Mortality Associated With Discontinuing Statins in Older Patients Receiving Polypharmacy.
JAMA Netw Open.
2021 Jun 1;4(6):e2113186.
doi: Cardiovascular Outcomes and Mortality Associated With Discontinuing Statins in Older Patients Receiving Polypharmacy.
10.
1001/jamaopen .
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