JAMA: TLR7 affects the risk of COVID19 in the elderly.

27 July 2020 // --- recent studies show that the coronavirus SARS-CoV-2 causes severe symptoms mainly in elderly patients with chronic diseases.
but doctors and researchers at Ladboud University Medical Center tend to believe that genetic factors play a key role in damaging the immune system in older people.
their study identified a key role in the immune response of gene TLR7 to SARS-CoV-2.
has potential implications for understanding and treating COVID-19.
In the first half of 2020, two of the COVID-19 patients in Dutch hospitals were both infected with THE SARS-CoV-2 virus and were in serious condition.
discovery has piqued the curiosity of doctors.
medics wanted to find out why the brothers were so badly affected.
sequenced all the genes of the two brothers, collectively known as exosomes, and the researchers combed the data to find possible common causes. "We focused on genes that play a role in the immune system," said Cas van der Made, a physician in the department of internal medicine at
.
(photo source: www.pixabay.com) we know that some of these genes are on the X chromosome, and that two brothers are affected, and the X chromosome gene is the most suspicious.
soon, the authors found mutations in genes that encode Toll-like receptor 7 (TLR7). "The genetic code of the TLR7 gene lacks a specific base," said
Hoischen.
results in it beunset to read properly and produce almost no TLR7 protein.
but surprisingly, we now have indications that TLR7 is critical to the protection of this coronavirus.
therefore, it appears that the virus can be replicated undisturbed because the immune system has not received a message that the virus has invaded.
because there is almost no TLR7 that must identify the intruder and then activate the defense.
this may be the cause of the brothers' serious illness.
" Van der Made and colleagues studied the consequences of TLR7's abnormal functioning.
"Once activated, TLR7 triggers the production of so-called interferons, a protein necessary to protect against viral infections."
this immune response may be even more important in the fight against the SARS-CoV-2 virus, as we know from the literature that the virus has the technique of reducing the production of interferon in immune cells.
When we simulated coronavirus infection, we found that immune cells in patients without TLR7 defects had little response and produced very few interferons.
these tests clearly show that the virus appears to have no control over the proper functioning of TLR7 in the body because the virus cannot be recognized by the immune system.
" (Bioon.com) Source: Researchers identify TLR7 gene this pre pre elders eldersssssssserly patientis patients to severe COVID-19 Original origin: Van der Made, C. I. , et al. (2020) Presence of The Wells Of Genetics Young Young With Men With Severe VID-19. JAMA. doi.org/10.1001/jama.2020.13719.