Japanese research team discovers new method to predict drug-induced liver injury

Recently, a research team from Yokohama City University in Japan discovered that the polygene structure can predict drug-induced liver injury

Drug-Induced Liver Injury (DILI) refers to the liver damage caused by the drug itself or /and its metabolites or due to the hypersensitivity or tolerance of the drug to the drug due to the special physique during the use of the drug

The prevention of drug-induced liver injury mainly depends on understanding the latest information on drug-induced liver disease, avoiding the use of drugs with liver damage as much as possible, and strengthening the monitoring of drug-induced liver disease, while the diagnosis of the disease is a diagnosis of exclusion, namely Need to rule out known causes of liver disease

The researchers established a polygenic risk score ( PRS) for drug-induced liver injury by summarizing the effects of numerous genome-wide loci identified in previous large-scale genome-wide association studies

This strategy may promote safer, more effective and more reliable clinical trial design

References: Masaru Koido, Eri Kawakami, Junko Fukumura, Yui Noguchi, Momoko Ohori ,etal.