echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Immunology News > JBC: Reveals the molecular mechanisms by which special cell proteins control the spread of cancer.

    JBC: Reveals the molecular mechanisms by which special cell proteins control the spread of cancer.

    • Last Update: 2020-09-09
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    August 16, 2020 // -- In-depth revelations about cellular signals that control cancer growth and migration may help in the search for effective anti-cancer drugs, scientists from Institutions such as McGill University have found or can help understand key biogenic processes of the pathogenesis of colorectal cancer in a recent study published in the international journal Journal of Biological Chemistry. In the
    paper, the researchers analyzed the behavior of key enzymes involved in the spread of cancer cells, noting that there may be a more refined interaction between an enzyme called PRL3 and another protein that moves magnesium ions inside and outside the cell, which is essential for the growth of colorectal cancer.
    image source: Unsplash/CC0 Public Domain researcher Dr Kalle Gehring says these enzymes first appear in liver cells that are activated to open up cell growth, so they may be able to act as growth signals; In this study, researchers found that the second activity of prL3 enzyme, the control of magnesium ion transport proteins, which guide the spread of cancer cells in other parts of the body, does not appear to catalytic activity, but binds closely to magnesium ion transport proteins and is as carcinogenic as wild proteins.
    The study raises long-standing questions about scientists' long-held hypothesis that PRL3 plays a key role in cancer diffusion, and the researchers believe that special binding mechanisms may be key to some extent; understanding the mechanisms by which binding to magnesium ion transport proteins, rather than the catalytic activity of enzymes, affects cancer growth and migration signals may hopefully help researchers identify new compounds to prevent cancer from spreading.
    Current drug screening for PRL3 focuses on finding compounds that block phosphatase activity, and by detecting the wrong function, this screening may miss out on other compounds that may have therapeutic potential, shifting the focus to enzyme activity that binds magnesium ion transport proteins may help many pharmaceutical companies better identify new cancer therapies through drug screening methods.
    later this year, researchers will continue to conduct more in-depth studies to analyze the key role magnesium ion transport proteins play in the spread of cancer and how they interact with PRL3.
    original source: Guennadi Kozlov et al, PRL3 pseudophosphatase activity is necessary and to promote metastatic growth, Journal of Biological Chemistry (2020). doi:10.1074/jbc. RA120.014464.
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.