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During pregnancy, the calcium (Ca) content in the mother's body changes to meet the fetus's calcium needs
.
It is unclear whether the reserves of parent minerals can meet these needs
During pregnancy, the calcium (Ca) content in the mother's body changes to meet the fetus's calcium needs
Methods: 18 to 45-year-old rural pregnant women (n=467) who participated in the prenatal nutritional supplement trial underwent pQCT scanning and blood sampling at 14 (3) and 31 (1) weeks of gestation
.
Results: Radius/tibia 4% total volume bone density, trabecular bone density, total cross-sectional area, 33%/38% radius/tibia cortical bone density, bone mineral content, total cross-sectional area, biochemical indicators: type 1 collagen interaction Linked β-C terminal peptide (β-CTX), type 1 procollagen amino terminal (P1NP), parathyroid hormone (PTH), parathyroid hormone (PTH), type 1 procollagen amino terminal (P1NP)
.
Independent tests test whether pooling or changes within the group are different from 0
Figure 1.
Changes in pQCT results of radius and tibia during pregnancy-related follow-up
.
Beta coefficient-the percentage coefficient of the change between two visits of pQCT bone results of the radius and tibia (mean [95% confidence interval])
Figure 1.
Figure 2 Changes in maternal bone turnover markers and bone biochemical analysis during pregnancy
.
β-Maternal biochemical and bone turnover markers Percentage coefficient of change in interval between visits (mean [95% confidence interval])
Figure 2 Changes in maternal bone turnover markers and bone biochemical analysis during pregnancy
Fig.
3 Differences in follow-up changes in the pQCT bone results of the radius and tibia in the folic acid + iron group and the supplement group during follow-up related to pregnancy
.
The β coefficient of the percentage difference between the pQCT bone results of the supplement group and the IFA reference group (mean [95% confidence interval]) in the radius (A) and tibia (B)
Fig.
Figure 4 Differences in pregnancy-related visits of bone metabolism markers and bone biochemical analytes between the folic acid+iron group and the supplement group
.
Beta coefficient (mean [SE]) of the difference in percentage changes of maternal biochemistry and bone turnover markers between the supplement group and the IFA reference group
Figure 4 Differences in pregnancy-related visits of bone metabolism markers and bone biochemical analytes between the folic acid+iron group and the supplement group
.
Beta coefficient (mean [SE]) of the difference in percentage changes of maternal biochemistry and bone turnover markers between the supplement group and the IFA reference group
.
The model was adjusted according to maternal age and supplement group
.
IFA = iron folic acid; MMN = multi-micronutrients; PE = protein energy; PE + MMN = protein energy and a variety of micronutrients; β-CTX = collagen type 1 cross-linked β-c terminal peptide; P1NP = type 1 procollagen n End; PTH = parathyroid hormone; TALP = total alkaline phosphatase
.
a P<0.
05; b P<0.
01; c P<0.
001
.
a b c
Conclusion: Although there is some evidence of changes in bone metabolism, in pregnant people with habitually low calcium intake, the amount of peripheral bone is insufficient to become a source of calcium for the fetus
.
.
Original source:
Ó Breasail M, Ward KA, Schoenbuchner SM,et al, Pregnancy-Related Change in pQCT and Bone Biochemistry in a Population With a Habitually Low Calcium Intake.
J Bone Miner Res 2021 Jul;36(7)
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