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    Home > Active Ingredient News > Digestive System Information > JCC: Curcumin Derivative Improves Crohn's Disease Symptoms

    JCC: Curcumin Derivative Improves Crohn's Disease Symptoms

    • Last Update: 2020-06-23
    • Source: Internet
    • Author: User
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    Background and objectives: The new curcumin derivative Theracurmin has a bioabsorption rate 27 times higher than natural curcumin powderTheracurmin is an inhibitor of NF-B, which inhibits the expression of inflammatory cytokinesThe study was designed to explore the efficacy and safety of Theracurmin in patients with Crohn's diseasemethod: This study was conducted at five independent medical centers in Japan, and Theracurmin used a 12-week treatment of Crohn's patients with mild to moderate activity (360 mg/day, n-20) or placebo (n s 10) to assess the efficacy of the drug by assessing clinical and endoscopic remission, the healing of lesions, and blood levels of inflammatory markersresults: In the Theracurmin group, a significant decrease in clinical disease activity was observed in week 12 relative to Week 0 (P - 0.005)In the intentional treatment analysis, the clinical remission rates at 4, 8 and 12 weeks were 35%, 40% and 40%, respectively, significantly higher than in the placebo group (both 0% ;P , 0.033, P - 0.020 and P , 0.020)In addition, the severity of endoscopy in patients with Crohn's disease was significantly reduced at the 12th week (15% VS 0%, P - 0.032), and lesions in the Theracurmin group at the 8th week were significantly healed (P - 0.017)No serious adverse events were observed in either group throughout the studyConclusion: Theracurmin showed significant efficacy in alleviating the severity of disease in patients with clinical and endoscopy efficacy
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