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Crohn’s disease (CD) is a chronic inflammatory bowel disease.
Approximately one-third of CD patients require bowel resection within five years after diagnosis.
Although the "biological era" has arrived, the surgical rate has dropped significantly.
But bowel resection is still the main treatment for CD
.
Disease recurrence in CD patients usually occurs in the new terminal ileum, and the Rutgeerts score can be used to judge the recurrence, which has been shown to predict important clinical outcomes including clinical recurrence and the need for further surgery
Crohn’s disease (CD) is a chronic inflammatory bowel disease.
This study included patients with CD who underwent ileocolectomy (ICR) in the final analysis, and serum samples from the patients were obtained during postoperative colonoscopy
.
Multiple immunoassays are used to analyze the correlation between 92 Olink Proteomics and CD disease
immunity
In this study, a total of 276 colonoscopy data were obtained from 213 patients
.
The median time from surgery to the first and second colonoscopy was 7 and 19 months, respectively
This study determined that many new candidate protein biomarkers are associated with postoperative recurrence of CD patients, especially the recurrence of CD after ileocolectomy
.
Among them, CXCR3 ligand has the most correlation with CD recurrence after ICR
This study determined that many new candidate protein biomarkers are associated with postoperative recurrence of CD patients, especially the recurrence of CD after ileocolectomy
Margaret Walshe.
A role for CXCR3 ligands as biomarkers of post-operative Crohn's disease recurrence.
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