JCC: Dietary patterns are associated with Crohn's disease remission time and gut microbiome composition
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Last Update: 2020-06-23
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Source: Internet
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Author: User
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Background and objectives: Crohn's disease (CD) is associated with changes in the composition and function of gut microbesThis study investigated the relationship between dietary intake patterns and baseline intestinal flora in patients with pallionation CD, and looked at the effects of dietary intervention on patients who ate non-diversified diets (NDDs)method: Researchers recruited 40 outpatients with palliated CDs in Calgary, Alberta, CanadaPatients who ate a lower plant-based, higher red and processed meat diet were assigned to the NDD group (n s 15) and received a 12-week structural dietary intervention, based on a 3-day food recordAll other patients were assigned to the DD control group (n s 25) and received routine treatmentFinally, the composition of fecal microbiome, short-chain fatty acids (SCFA) and calcin levels were measuredresults: At baseline, the fecal microorganism beta diversity in the NDD and DD groups is different (p s 0.003)The NDD group had a lower Populationalili-bacteriuum and a higher Ecoli/Shiga bacteria, and the relative abundance of the DD group (3.3 to 5.4% VS 8.5 to 10.6%; 6.9 to 12.2% VS 1.6 to 4.4%; p.03These two genus exhibit a strong negative correlation (r s - -0.60, q - 0.0002)Fecal butyric acid is positively correlated with Ferxea (r s s s 0.52, q s 0.002)After 12 weeks of dietary intervention, there was no difference in microbial beta diversity between the two groups (p - 0.43)The NDD group demonstrates an increase in p.05,GEE, similar to the DD group at the end of the intervention (p s 0.84)We did not find a diet associated with fecal SCFA or calcinconclusion: Dietary patterns are associated with specific intestinal microbiome composition in patients with CD during the remission periodDietary interventionin in patients who ingestNDD changes the composition of the gut microbiome
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