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Background and objective: Interstitial stem cells (MSCs) are used to treat immunomediated diseases due to their immune regulatory propertiesCell therapy for MSCs induces multiple effects in the immune system, which eventually leads to an increase in the number of immune cells that regulate the epiatformFor the study, researchers investigated whether the beneficial effects of MSC could be sustained over time in clinically relevant mouse models of colitismethod: During the induction phase of the disease, single-dose MSC (aMSC) of the fat source is injected into ecoli mice induced by sodium glucan sulfate (DSS)After a 12-week incubation period, the mice were again evaluated for colitis with a second 7-day DSS cycleresults: Compared to mice with DSS-induced colitis that were not treated with aMSC, DSS-induced colitis mice treated with aMSC showed significant decreased intestinal disease activity index during the second DSS inductionSurprisingly, long-term protection induced by aMSC therapy was also observed inmice without adaptive immune memory cell response12 weeks after the first inflammatory attack, in the peritoneal cavity, spleen and bone marrow of mice injected with aMSC-induced DSS, an increase in the percentage of Ly6G-
CD11b-
myelin cells was foundInterestingly, after re-attacking with DSS, the proportion of these animals in the inherent layers of the colon increased in proportion to regulatory/inflammatory macrophagesConclusions The results of this study show for the first time that MSC therapy can produce a congenital immune memory-like response in mice, providing long-term and sustained protection against acute inflammation