JCC: Patients diagnosed with Crohn's disease after anti-tb therapy are more likely to have intestinal stenosis

Background and objectives: Anti-TB therapy (ATT) treatment is a common strategy in TB-endemic countries in cases where diagnosis difficulties are present for intestinal tuberculosis and Crohn's disease (CD)The purpose of this study is to determine the results of long-term clinical outcomes in patients receiving ATT before the final diagnosis of CDmethod: The researchers reviewed CD patients who received ATT for 6 months with cd patients who did not receive ATTThe results of the assessment were changes in disease behavior, surgical requirements and drug use during follow-upresults: The study screened 760 CD patients for study and compared 79 patients in each group after a preference match between the location and behavior of the diseaseProgress from narrow-free penetration (B1) to narrow/fistula (B2/B3) phenotype was more likely to progress in CD patients receiving ATT (B1, B2, B3 - baseline 73.4%, 26.6%, 0%, baseline, 41.8%, 51.9%, 6.33, baseline, respectively The proportion of patients who did not receive ATT was 11.05 (3.17 - 38.56) compared to patients who did not receive ATT (B1, B2, B3 - 73.4%, 26.6%, 0% at baseline, 72.2%, 27.8%, 0% at baseline)The use of 5-ASA, steroids, immunosuppressants, and anti-TNF is similar between the two groupsIn the survival analysis, CD patients who received ATT were less likely to remain surgical-free during 14 years of follow-up (45%) than those who did not receive CD (76%) (HR - 3.22 (95% CI, 1.46-7.12), p - 0.004)conclusion: The long-term course of disease diagnosed in Crohn's disease after testing of anti-tuberculosis therapy is unfavourable, the rate of stenosis formation is higher, and the need for surgery is higher