JCC: Professor Hu Jianguo from the First Affiliated Hospital of Beng Medicine has made important progress in the research on the mechanism of mesenteric lesions of Crohn's disease

Recently, the research team of the Inflammatory Bowel Disease Research Center of the First Affiliated Hospital of Beng Medicine has made important progress in the study of the mechanism of mesenteric lesions of Crohn's disease.
"Role of TLR-4-mediated Macrophages" was published in "Journal of Crohn's and Colitis" (the first district of Chinese Academy of Sciences, IF: 10.
02), an international authoritative journal of the European Organization for Crohn's Disease and Colitis.
This study revealed for the first time adipose tissue Extracellular matrix (ECM) remodeling is involved in the mechanism of mesenteric lesions in Crohn's disease and proposes new potential therapeutic targets
.
The First Affiliated Hospital of Beng Medicine is the independent first author and corresponding author unit
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Professor Hu Jianguo is the corresponding author of the paper, and researchers such as Zuo Lugen, Li Jing, Zhang Xiaofeng, Geng Zhijun, Song Xue, Wang Yueyue and Ge Sitang participated in the completion of the paper
.
This is the second time the team has published research results in the Journal of Crohn's and Colitis after 2019
.

Crohn's disease (CD) is a chronic, segmental enteritis with a tendency for life-long relapse, with unknown pathogenesis and incurable characteristics
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The incidence of this disease in China is increasing year by year, and it mainly affects the young and middle-aged people, which is of great social harm
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Previous studies on the CD bowel itself could neither reasonably interpret the laws of the disease nor propose more effective treatment methods
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However, in addition to enteritis, CD is also characterized by inflammatory hyperplasia of mesenteric adipose tissue, and the diseased adipose tissue can participate in the progression of enteritis by expressing adipokines
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This provides a new perspective for the disclosure of CD pathogenesis and the innovation of diagnosis and treatment strategies
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However, the mechanisms of CD mesenteric lesions and how to translate them into clinical therapeutic targets remain to be revealed
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In this study, the in-depth study of mesenteric adipose tissue specimens, primary mesenteric inflammatory cells and animal models from patients with CD found that there is an ECM remodeling phenomenon characterized by simultaneous active synthesis and degradation of extracellular matrix (ECM) in the mesenteric adipose tissue of patients with CD.
; This process leads to abnormal morphology and mechanical stress of adipocytes, and the inflammatory factors produced by the ECM remodeling process together lead to adipocyte dysfunction, and induce the expression of inflammatory adipokines in adipocytes to exacerbate enteritis; in vivo and in vitro analysis showed that TLR4 signaling regulates The macrophages play a key role in the process of ECM remodeling.
Knockout of macrophages or inhibition of TLR4 signaling can block the process of ECM remodeling in the mesenteric adipose tissue of CD model mice, and simultaneously improve mesenteric and enteritis lesions
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This study discovers and explains the phenomenon and mechanism of ECM remodeling in CD mesenteric adipose tissue, and proposes that blocking ECM remodeling is a potential new approach for CD therapy
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The research was funded by the National Natural Science Foundation of China, the Incubation Program of Major Science and Technology Projects of Bengbu Medical College, the "512 Talent Cultivation Program" of Bengbu Medical College, and the Outstanding Youth Fund of the First Affiliated Hospital of Bengbu Medical College
.

Original link:

https://doi.
org/10.
1093/ecco-jcc/jjac087