JCC: Raman spectroscopy can identify biochemical differences in plasma in patients with Crohn's disease
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Last Update: 2020-06-23
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Source: Internet
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Author: User
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Background and objectives: There are currently no accurate and reliable circulatory biomarkers that can be used to diagnose Crohn's disease (CD)Raman spectroscopy is a relatively new method that provides information on the biochemical composition of a sample in minutesThe purpose of this study is to test the use of Raman spectroscopy of plasma samples as a potential diagnostic tool for CDmethod: The researchers analyzed plasma samples from 77 CD patients (CDs) and 45 healthy controls (HC) using Raman spectroscopyIn the data set, the researchers analyzed spectral differences between CDs and HC and cd patients with different disease behaviorsThe researchers also developed a method based on the main component analysis and then linear discrimination analysis (PCA-LDA), which automatically classifies individuals based on plasma spectroscopyresults: Compared to HC, the CD spectrum is characterized by a lower intensity peak (p 10-4) and a higher intensity peak (p 10-4) corresponding to a protein with a beta-folding secondary structureDifferences were also found with Raman peaks compared to lipids (p s 0.0007) and aromatic amino acids (p 10-4)The predictive models developed by the researchers classified CD and HC subjects with an accuracy of 83.6% (sensitivity of 80.0% and 85.7% specificity) and an F1 score of 86.8%conclusion: Plasma Raman spectroscopy can identify CD-related metabolic changes, and it can be used as a quick prescreening
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