echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Digestive System Information > JCC: Raman spectroscopy can identify biochemical differences in plasma in patients with Crohn's disease

    JCC: Raman spectroscopy can identify biochemical differences in plasma in patients with Crohn's disease

    • Last Update: 2020-06-23
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    Background and objectives: There are currently no accurate and reliable circulatory biomarkers that can be used to diagnose Crohn's disease (CD)Raman spectroscopy is a relatively new method that provides information on the biochemical composition of a sample in minutesThe purpose of this study is to test the use of Raman spectroscopy of plasma samples as a potential diagnostic tool for CDmethod: The researchers analyzed plasma samples from 77 CD patients (CDs) and 45 healthy controls (HC) using Raman spectroscopyIn the data set, the researchers analyzed spectral differences between CDs and HC and cd patients with different disease behaviorsThe researchers also developed a method based on the main component analysis and then linear discrimination analysis (PCA-LDA), which automatically classifies individuals based on plasma spectroscopyresults: Compared to HC, the CD spectrum is characterized by a lower intensity peak (p 10-4) and a higher intensity peak (p 10-4) corresponding to a protein with a beta-folding secondary structureDifferences were also found with Raman peaks compared to lipids (p s 0.0007) and aromatic amino acids (p 10-4)The predictive models developed by the researchers classified CD and HC subjects with an accuracy of 83.6% (sensitivity of 80.0% and 85.7% specificity) and an F1 score of 86.8%conclusion: Plasma Raman spectroscopy can identify CD-related metabolic changes, and it can be used as a quick prescreening
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.