JCC: The fecal calprotectin content of ileostomy excretion can well predict the degree of small bowel inflammation in patients with Crohn's disease

Crohn's disease (CD) is an idiopathic chronic inflammatory bowel disease, and severe Crohn's disease (CD) can lead to extensive bowel resection and require ileostomy
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Calprotectin is a calcium and zinc binding protein belonging to the S-100 protein family

Crohn's disease (CD) is an idiopathic chronic inflammatory bowel disease, and severe Crohn's disease (CD) can lead to extensive bowel resection and require ileostomy

 

The researchers retrospectively analyzed the clinical cases of adult patients whose ICD-10 code is CD in the Mayo Clinic electronic medical record from January 1, 2017 to September 30, 2020, and the ileostomy History of surgery
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If the patient has measured FC at least once and simultaneously undergoes radiography and/or endoscopy, the patient is included in the analysis

 

A total of 51 patients met the inclusion criteria, of which 17 patients had FC levels >60 mcg/g
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Of these 17 patients, 14 were confirmed to have small bowel inflammation through imaging and/or ileoscopy, with a sensitivity of 87.

diagnosis

 

This study confirms that FC from ileostomy effluent is a highly sensitive biomarker that can be used to assess and monitor small bowel inflammation and disease recurrence in patients with CD
.

This study confirms that FC from ileostomy effluent is a highly sensitive biomarker that can be used to assess and monitor small bowel inflammation and disease recurrence in patients with CD
.

 

 

Original source:

Nader D Daoud.

Fecal Calprotectin from Ileostomy Output is Sensitive and Specific for the Prediction of Small Bowel Inflammation in Patients with Crohn's Disease.
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