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Fecal transplantation (FMT) may sound incredible, but the use of feces has long been a hot area of research in the medical community.
as the name suggests, a fecal transplant is the delivery of one person's stool through the intestines to another.
aims to transplant beneficial microorganisms from a healthy person's intestines into a problem recipient and to treat the disease.
don't look down on the process, it has the risk of saving some people's lives.
fecal microbiome transplantation (FMT) has been shown to be effective in inducing remission in patients with active ulcerative colitis (UC).
there is no consensus on what factors affect the effectiveness of FMT, so this study aims to do the same.
researchers treated patients with ulcerative colitis who performed fecal transplants with FMT through colonoscopy at weeks 0, 2, 6, 10, 14, 18 and 22.
response to FMT is defined as clinical remission of corticosteroid-free at the 30th week.
results showed that out of 140 active UC patients treated with FMT, a total of 93 patients completed the multi-stage FMT program (average age 34.96 to 11.27 years old, 62.36 percent for men, and an average score of 8.07 to 2.00) at the Mayo Clinic.
57 patients (61.29%) achieved clinical remission.
age (OR 0.93, 95% CI: 0.89-0.97, p-0.001), moderate (Mayo clinical score 6-9), disease severity (OR 3.01,95% CI 1.1 2 to 8.06, p s 0.025) and endoscope Mayo score 2 (OR 5.55, 95% CI 2.18-14.06, p slt;0.001) are indicators of significant predictive mitigation in a single-factor analysis.
age, disease level E2 and endoscope Mayo score 2 (OR 0.925, 95% CI 0.88-0.97, p s 0.002; OR 2.89,95%CI 1.01-8.25, p s 0.04 and OR 8.43, 95% CI 2.38-29.84, p s 0.001) were associated with clinical regression of multi-factor logistic regression, respectively.
younger age, disease level e2 and endoscope Mayo score 2 were effective predictive factors for FMT clinical remission in active UC patients.
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