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It is not clear what the long-term risk of developing type 2 diabetes in adolescents with non-alcoholic fatty liver disease (NAFLD).
, researchers aim to assess the risk of type 2 diabetes in NAFLD adolescents, according to a recent study published in Journal of Clinical Endocrinology and Metabolism, an authoritative journal in the field of endocrinology and metabolic diseases.
this national population study of Israeli adolescents, who under conducted medical examinations prior to their military service from 1997 to 2011 and followed them until 31 December 2016.
the study included 1025,796 adolescents with normal blood sugar.
biopsy or X-ray are the main means of diagnosing NAFLD.
data have been linked to the Israeli National Diabetes Registry.
the study was the incidence of type 2 diabetes.
12 out of 633 adolescents with NAFLD (1.9 per cent; all patients with higher baseline BMI levels) were diagnosed with type 2 diabetes during an average follow-up period of 13.3 years, while 2917 (0.3 per cent) were diagnosed without NAFLD.
after adjusting for a mix of factors such as BMI and socio-demographic indicators, the risk ratio of type 2 diabetes (HR) between NAFLD and non-NAFLD groups was 2.59 (95% CI 1.47-4.58).
in several sensitivity analyses, high risk persists.
these analyses included a population analysis of no other metabolic comedies (corrected HR of 2.75 (95% CI of 1.48-5.14)) and high BMI.
When reference is made to a control of gender, year of birth, and BMI matching, the results are still significant (corrected HR is 2.98 (95% CI is 1.54-5.74).
, NAFLD was associated with an increased risk of type 2 diabetes in adolescents with normal blood sugar.
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