JCEM: Amino acid metabolism mediates the association between gut microbes and osteoporosis

Some small studies have shown that gut microbes may affect osteoporosis , but no relevant evidence has been found from human metabolomics studies to explain this association

Recently, a research article was published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, which aims to explore the relationship between gut microbiota disorders and osteoporosis through fecal and serum metabolomics And explored the underlying mechanism of this association

Researchers used 16S rRNA and dual-energy x-ray bone mineral density (BMD) to analyze the gut microbiota composition and bone mineral density (BMD) of 1,776 community-based adults, and used ultra-high performance liquid chromatography-tandem mass spectrometry ( UPLC-MS/MS) further analyzed the targeted metabolomics of feces (15 categories) and serum (12 categories) of 971 subjects

Research design drawings and main research results

The study found that osteoporosis is related to the diversity, classification and functional composition of intestinal microbes

This study based on a large population provides strong evidence of a correlation between intestinal disorders, fecal metabolomics and serum metabolomics and osteoporosis

Original source:

Chu-wen Ling.