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The role of vitamin D status in COVID-19 patients is debatable.
recently, a research paper was published in Journal of Clinical Endocrinology and Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, to assess serum 25-hydroxyvitamin D (25OHD) levels in hospitalized COVID-19 patients and to analyze the effects of vitamin D status on the severity of the disease.
retrospective case control study included 216 COVID-19 patients and 197 population-based controls.
subjects measured serum 25OHD levels in both groups.
, the relationship between serum 25OHD levels and the severity of COVID-19 (to be admitted to an intensive care unit, requiring mechanical aeration or death) was assessed.
19 of the 216 patients were treated with vitamin D supplements and analyzed separately.
in patients with COVID-19, the average ±SD level of 25OHD was 13.8±7.2 ng/ml, compared with 20.9±7.4 ng/ml in the control group.
25OHD in men was lower than in women, vitamin D deficiency was found in 82.2% of COVID-19 cases and 47.2% of population controls .
25OHD levels were inversely inversely related to serum ferrin (p=0.013) and D-d-djumer levels (p=0.027).
patients with
vitamin D deficiency had a higher prevalence of hypertension and cardiovascular disease, elevated levels of serum ferrin and tsporine, and longer hospital stays than those with 25OHD≥20 ng/ml.
cause-and-effect relationship between vitamin D deficiency and the severity of COVID-19.
, the prevalence of deficiency was higher in hospitalized COVID-19 patients with lower levels of 25OHD than in population-based control groups.
researchers found no link between vitamin D concentrations or vitamin deficiency and the severity of the disease.