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JCEM: Association of long-term proton pump inhibitor use with risk of type 2 diabetes

 Last Update: 2022-05-09
 Source: Internet
 Author: User

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Proton pump inhibitors (PPIs) long-term inhibit basal and food-stimulated gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase (or proton pump) of gastric parietal cells

Digestion

Recently, a research article was published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases.

diabetes

Researchers conducted a case-control study in Lombardy, Italy, of 777,420 patients newly treated with PPIs between 2010 and 2015

The incidence of diabetes was 19% (95% CI 15-24) in patients who used PPIs for 8 weeks to 6 months, 6 months to 2 years, and >2 years compared with those who used PPIs for <8 weeks.

CONCLUSIONS: Regular and long-term use of PPIs is associated with a higher risk of diabetes

Regular and long-term use of PPIs is associated with a higher risk of diabetes

Original source:

Stefano Ciardullo, et al.

Prolonged use of proton pump inhibitors and risk of type 2 diabetes: results from a large population-based nested case-control

study

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