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Observational studies have shown that NAFLD is closely associated with serum uric acid
.
However, these studies have an inherent risk of bias due to the negative causal relationship between them
In this study, researchers used a Mendelian randomization (MR) study to investigate the relationship between serum uric acid levels and non-alcoholic Causal relationship between fatty liver disease
.
We performed two two-way MR analyses of pooled data from a genome-wide association study ( GWAS ) of serum uric acid (110,347 individuals) and nonalcoholic fatty liver disease (1,483 cases and 17,781 controls) in a European population
.
First, we selected 13 single nucleotide polymorphisms (SNPs) associated with serum uric acid as tools to estimate the causal effect of elevated serum uric acid levels on nonalcoholic fatty liver disease risk using an inverse variance weighted (IVW) approach
GWAS
The researchers' MR analysis showed that NAFLD was associated with serum uric acid levels (β=0.
032, p=0.
003)
.
Similar results were obtained using other MR methods and sensitivity analyses
CONCLUSIONS: This study supports a causal relationship between NAFLD-induced elevated serum uric acid levels, but the study did not demonstrate a causal relationship between serum uric acid levels and NAFLD risk
.
The underlying mechanism needs to be further studied
This study supports a causal relationship between NAFLD and increased serum uric acid levels, but the study did not demonstrate a causal relationship between serum uric acid levels and NAFLD risk
Original source:
Shiwei Li, et al.
Shiwei Li, et al.
Serum Uric Acid Levels and Non-alcoholic Fatty Liver Disease: A Two-sample Bidirectional Mendelian Randomization Study .
JCEM.
2022.
https://academic.
oup.
com/jcem/advance-article/doi/10.
1210 /clinem/dgac190/6562281 Serum Uric Acid Levels and Non-alcoholic Fatty Liver Disease: A Two-sample Bidirectional Mendelian Randomization StudyLeave a Comment here
