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The relationship between changes in circulating microRNA-122 (miR-122) and liver fat after weight loss interventions has not been elucidated
A study published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, aimed to investigate the relationship between miR-122 levels and changes in liver fat content during an 18-month diet and physical activity intervention.
The CENTRAL trial was an 18-month randomized controlled trial in adults with abdominal obesity or dyslipidemia
Serum miR-122 levels increased significantly from baseline to 18 months, while no differences were observed between the four intervention groups
CONCLUSIONS : Participants with higher serum miR-122 levels may have less benefit in reducing liver fat content due to dietary and physical activity interventions
Participants with higher serum miR-122 levels may have less benefit in reducing liver fat content due to dietary and physical activity interventions
Original source:
Mengying Wang.
Circulating levels of microRNA-122 and hepatic fat change in response to weight-loss interventions: CENTRAL
Trial