JCEM: Differences in mitochondrial gene expression in adipose tissue after weight loss through diet or bariatric surgery

Mitochondrials are essential for cellular energy stability, but the role of mitochondrials in subsulpheric adipose tissue (SAT) is not clear in different types of weight loss interventions.
a recent study published in Journal of Clinical Endocrinology and Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, aims to investigate changes in SAT mitochondrials after weight loss through four independent weight loss intervention studies.
DiOGenes study is a European multi-center dietary intervention using an 8-week low-calorie diet (LCD; 800 kcal/d; n-261) and 6-month weight maintenance (n-121).
Kuopio Obesity Surgery Study (KOBS) is a Roux-en-Y gastric bridge (RYGB) study (n-172) that conducted a one-year follow-up.
linear regression analysis, adjusted for age and gender, the researchers correlated the percentage of weight loss with the overall and 2,210 mitochondrial-related RNA transcripts.
the researchers repeated these findings in two studies.
6 weeks of LCD (800-1000 kcal/d; n=19) and 10.5 month follow-up sessions in the Finnish CRYO study.
Swedish DEOSH study is a RYGB study that followed for 2 years (n-49) and 5 years (n-37).
weight loss caused by diet led to a significant reduction in transcription of phosphate-related genes (DiOGenes; Original Pathway Analysis (IPA) Z value: -8.7 after LCD, -4.4 after weight maintenance; CRYO: IPA Z value: -5.6, all p.lt. 0.001), while the above genes were increased for surgically induced weight loss subjects (KOBS: IPA z-score: 1.8, p.lt;0.001; in the DEOSH study: IPA z score: 4.0 after 2 years and 0.0 after 5 years).
confirmed an increase in proteomics levels of oxidizing phosphate after surgery (IPA z score: 3.2, p.lt;0.001).
, it can be seen that the differentiated regulation of SAT mitochondrial-related gene expression indicates a qualitative change between different weight loss interventions, which provides potential molecular intervention targets for weight loss success.