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    Home > Active Ingredient News > Endocrine System > JCEM: Effect of mineralocorticoid receptor antagonist on the ratio of aldosterone to renin in patients with primary aldosteronism

    JCEM: Effect of mineralocorticoid receptor antagonist on the ratio of aldosterone to renin in patients with primary aldosteronism

    • Last Update: 2021-05-20
    • Source: Internet
    • Author: User
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    Recently, a research article was published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases.


    The researchers prospectively recruited 121 patients who had been diagnosed with primary aldosteronism, and they began treatment with a mineralocorticoid receptor antagonist (canrenone).


    Eighteen patients (11 patients with unilateral hyperaldosteronism and 7 patients with bilateral primary hyperaldosteronism) formed a short-term study cohort, and the subjects' aldosterone was measured after 2 and 8 weeks of canrenone treatment , Renin and blood potassium levels.


    After short-term and long-term treatment, the ratio of aldosterone to renin was significantly lower than that at baseline.


    Screening diagnosis

    Therefore, patients with hypertension should avoid using mineralocorticoid receptor antagonists before measuring renin and aldosterone levels to screen for primary aldosteronism .


    Patients with hypertension should avoid mineralocorticoid receptor antagonists before measuring renin and aldosterone levels to screen for primary aldosteronism

    Original source:

    Original source:

    Alessio Pecori.


    org/10.
    1210/clinem/dgab290" target="_blank" rel="noopener">Mineralocorticoid receptor antagonist effect on aldosterone to renin ratio in patients with primary aldosteronism

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